life sciences institute of new jersey (lsinj)

Mission Statement

The LSINJ is a nonprofit private foundation with the mission of 'preempting genetic diseases and birth defects' with a Combinatorial Approach. This is the only real cure for intractable diseases. Studies have projected that 65% of all diseases have a genetic (40%) or genetic and environmental (25%) basis with annual costs of several $100 trillions. At least 13700 causal single genes display Mendelian Inheritance. Every year, about 3 - 6% of infants, at an incidence rate of approximately 10/1000 births worldwide, are born with serious diseases. We believe that everyone has the right to health. We use our resources to solve the larger problems afflicting Humankind with the objective of building a better society.


(For the approach of the LSINJ to eventual preemption scroll down to link and figures 1 & 2 in the section following Model Scientists)

The LSINJ draws on Scientists who were at the very pinnacle of their fields with all its associated authority. They chose instead to uphold the Public Interest or Common Good which inevitably contradicted their personal interests. They fully appreciated the magnitude of the consequences of such dissidence and became recognized as Figures of History.

"Andrei Dmitrievich Sakharov (Russian: Андре́й Дми́триевич Са́харов; 21 May 1921 – 14 December 1989) was a Russian nuclear physicist, dissident, Nobel laureate, and activist for disarmament, peace and human rights.[1]

He became renowned as the designer of the Soviet Union's RDS-37, a codename for Soviet development of thermonuclear weapons. Sakharov later became an advocate of civil liberties and civil reforms in the Soviet Union, for which he faced state persecution; these efforts earned him the Nobel Peace Prize in 1975. The Sakharov Prize, which is awarded annually by the European Parliament for people and organizations dedicated to human rights and freedoms, is named in his honor.[2] "

"Julius Robert Oppenheimer[note 1] (/ˈɒpənˌhaɪmər/; April 22, 1904 – February 18, 1967) was an American theoretical physicist and professor of physics at the University of California, Berkeley. Oppenheimer was the wartime head of the Los Alamos Laboratory and is among those who are credited with being the "father of the atomic bomb" for their role in the Manhattan Project, the World War II undertaking that developed the first nuclear weapons. The first atomic bomb was successfully detonated on July 16, 1945, in the Trinity test in New Mexico. Oppenheimer later remarked that it brought to mind words from the Bhagavad Gita: "Now I am become Death, the destroyer of worlds."[2][note 2] In August 1945, the weapons were used in the atomic bombings of Hiroshima and Nagasaki.

After the war ended, Oppenheimer became chairman of the influential General Advisory Committee of the newly created United States Atomic Energy Commission. He used that position to lobby for international control of nuclear power to avert nuclear proliferation and a nuclear arms race with the Soviet Union. After provoking the ire of many politicians with his outspoken opinions during the Second Red Scare, he suffered the revocation of his security clearance in a much-publicized hearing in 1954, and was effectively stripped of his direct political influence; he continued to lecture, write and work in physics. Nine years later, President John F. Kennedy awarded (and Lyndon B. Johnson presented) him with the Enrico Fermi Award as a gesture of political rehabilitation."

"A knowledge of the historic and philosophical background gives that kind of independence from prejudices of his generation from which most scientists are suffering. This independence created by philosophical insight is — in my opinion — the mark of distinction between a mere artisan or specialist and a real seeker after truth.

-Albert Einstein, Letter to Robert Thornton, 1944"

"I understand I am here this evening because the maize plant, with which I have worked for many years, revealed a genetic phenomenon that was totally at odds with the dogma of the times, the mid-nineteen forties. Recently, with the general acceptance of this phenomenon, I have been asked, notably by young investigators, just how I felt during the long period when my work was ignored, dismissed, or aroused frustration. At first, I must admit, I was surprised and then puzzled, as I thought the evidence and the logic sustaining my interpretation of it, were sufficiently revealing. It soon became clear, however, that tacit assumptions – the substance of dogma – served as a barrier to effective communication. "

-Barbara McClintock, 1983


From Les Prix Nobel. The Nobel Prizes 1983, Editor Wilhelm Odelberg, [Nobel Foundation], Stockholm, 1984

Ferez S. Nallaseth, MS, PhD, #BeyondNobels #QED "quod erat demonstrandum"- LinkedIn Feed

Richard Feynman@ProfFeynman, Mar 14, 2019, "Relativity applies to physics, not ethics."

Richard Feynman@ProfFeynman, Mar 14, 2019, "He wore his sweater, without a shirt under it, no socks - just like everybody says - and was such a soft, nice man in the discussions, at all points. He was such an interesting man to talk to. Happy Birthday Albert EINSTEIN (1879 - 1955)"

Richard Feynman@ProfFeynman

https://twitter.com/search?q=Prof.Feynman&src=typed_query

Richard Phillips Feynman,[2][3][4] ForMemRS (/ˈfaɪnmən/; May 11, 1918 – February 15, 1988) was an American theoretical physicist, known for his work in the path integral formulation of quantum mechanics, the theory of quantum electrodynamics, the physics of the superfluidity of supercooled liquid helium, as well as his work in particle physics for which he proposed the parton model. For contributions to the development of quantum electrodynamics, Feynman received the Nobel Prize in Physics in 1965 jointly with Julian Schwinger and Shin'ichirō Tomonaga. During his lifetime, Feynman became one of the best-known scientists in the world. In a 1999 poll of 130 leading physicists worldwide by the British journal Physics World, he was ranked as one of the ten greatest physicists of all time.[5] Feynman was a keen popularizer of physics through both books and lectures, including a 1959 talk on top-down nanotechnology called There's Plenty of Room at the Bottom , his undergraduate lectures, The Feynman Lectures on Physics, his semi-autobiographical books Surely You're Joking, Mr. Feynman! and What Do You Care What Other People Think?, and books written about him such as Tuva or Bust! by Ralph Leighton and the biography Genius: The Life and Science of Richard Feynman by James Gleick.

https://en.wikipedia.org/wiki/Richard_Feynman

Figure 1

Figure 2

LSINJ - Why is Preempting Genetic Lesions and Birth Defects Possible?

Akin to the Great Revolutions or Ages, the Combinatorial Approach for Preempting Genetic Diseases Requires the Confluence of Independent Scientific and Societal Developments Emerging from Synergisms Between Serendipitous, Planned and Natural Progressions Significantly Magnifying the Impact Over the Simple Sum of their Individual Components or Subfields

Ferez Soli Nallaseth1*, Mohammed Abouelsoud1, David Adebayo1, Syed Ahmed1, Kholis Abdurachim Audah1, Deepak Bhatia1, Vitaly Boyko1, Alex Diaz1, Abhishek Gupta1, Mirhasan H Hasanli1, Percy Ichchaporia1, Zeeshan Khan1, Anthony Lai1, Lori McGrew1, Shin Mukai1, Dickson Achimugu Musa1, Srinath Nissankararao1, Elizabeth Parrish1, George Perry2, Jean Plante1, Asmaa Rabit1, David Sherman1, Ralph Sherman1, Sandeep Kumar Singh1, Sina Varmaghani1, Collin C White1, Nirmali Wijegoonawardana1, Hafiz Shaeque Yahya1 and Osama Youssef2

*Corresponding Author: Ferez Soli Nallaseth, Founding President, CEO, CSO and CFO for the LSINJ, USA. Postal Addresses: Life Sciences Institute of New Jersey, Email: FerezNallaseth@LifeSciencesInstituteNJ.com;

https://actascientific.com/ASMI/pdf/ASMI-04-0918.pdf

Reasons and Methods for the Mission of the LSINJ in Preempting Genetic Diseases and Birth Defects - the Where, the Why, the How, the When and the Wherefore ?

Selected Publications relevant to the Mission of the LSINJ

Why does the LSINJ need Donations ? A statement and Why donate?

As an institute the LSINJ advocates for meeting the single greatest challenge in Medicine. This is the preemption rather than the management of genetic diseases and birth defects. These lesions are recognised as a contributing component for 65% of all diseases that conservatively cost hundreds of trillions of dollars per year. The generational nature of the undertaking to meet this challenge in tangible ways, as well as the necessity of integration of seemingly unrelated and even disparate fields, makes it unattractive to funding agencies. Yet there is no work of greater significance, impact and necessity in the Public Interest in Life Sciences and Medicine. We have used personal donations to support this core mission but its fulfillment requires expanded funding.

Although a large body of work supporting our enterprise already exists, the understanding of relevant mechanisms and molecules for inserting disease lesions remains mired at the level of Models. Consequently resulting in an exclusive management of post-mutational therapy ratgher than preemption of genetic disease lesions. Furthermore there is a perpetuation of recurrent insertions of genetic disease lesions, expanding patient poulations. This body of work emerging over, as much as the last ~150 years, done by millions of Scientists comprises of hundreds of millions of papers, data sets, results and methods in all the relevant sciences.

By using a combinatorial method this contradiction can be resolved and relevant mechanisms of dys-regulation identified. Evolutionary Genetics Principle of Species Incompatibility generates and permits Discovery of relevant dys-regulated mechanisms for insertions of relevant genetic lesions. While the power of high resolution contemporary methods permits Analyses of the dys-regulated mechanisms. The Combinatorial Approach (CA) is a combination of all these methods which are eventually applied to preempting genetic disease lesions in humans in Real Time Operations (RTO) or CA RTO. Advocacy of this shift in the current paradigm of Medicine with CA RTO is the core mission of the LSINJ with the goal of eventually melding it with relevant Experimental work.

REFERENCES:

Akin to the Great Revolutions or Ages, the Combinatorial Approach for Preempting Genetic Diseases Requires the Confluence of Independent Scientific and Societal Developments Emerging from Synergisms Between Serendipitous, Planned and Natural Progressions Significantly Magnifying the Impact Over the Simple Sum of their Individual Components or Subfields

Ferez Soli Nallaseth1*, et al ,*Corresponding Author: Ferez Soli Nallaseth, Founding President, CEO, CSO and CFO for the LSINJ, USA. Postal Addresses: Life Sciences Institute of New Jersey, Email: FerezNallaseth@LifeSciencesInstituteNJ.com; fereznal25@lsinj.org

https://actascientific.com/ASMI/pdf/ASMI-04-0918.pdf


Is There a Role for an Evolutionary Genetics Based Rational Health Policy In Global Biomedical, Health and Economic Policies? Nallaseth. J. Mol Biol OMICS . v3 :1.6.30.2014, (http://dx.doi.org/10.4172/2168-9547.1000e118)

EXTENDED LIST OF RELEVANT REFERENCES

https://sites.google.com/d/1f4CViSjH_ZmRxmLbfdVa4I_zqSHzTgGi/p/1sedMxFzSyBHbXKZpczcYV1cdVHZKRn4J/edit

Serendipitous contributions of the LSINJ as a consequence of its core scientific mission of preempting genetic disease lesions - a Public Service. Addressing a significant driver of the COVID - 19 Pandemic by preempting the generation of mutations in viral genomes e.g. SARS-Cov-2.

Multi-dimensional factors driving the pandemic and how their impact decides any return to the pre-COVID-19 world! (How and when should we begin playing Squash? As with everything in the post COVID-19 world - considering the stakes – very slowly and carefully!)

Kholis Abdurachim Audah Ph.D.$, Dickson Achimugu Musa Ph.D.#, David Adebayo, Syed Mahmood Ahmed Ph.D., Alex Diaz Ph.D., Abhishek Gupta Ph.D., Percy Ichchaporia M.S., Anthony Lai M.B.B.S., M.D., F.A.C.O.G., Lori McGrew Ph.D.++, Moyosola Otusanya M.S., Elizabeth Parrish, Jean Plante@, Asmaa Rabit D.G.M. & D., Ralph Sherman B.S., Sina Varmaghani M.S., Collin C. White B.S., Nirmali Wijegoonawardana Ph.D., Rebecca Xu, Hafiz Yahya Ph.D., Poorna C.R. Yalagala Ph.D., Osama Youssef Ph.D., Alan Thatcher +1,%, George Perry Ph.D.+2,%, Ferez Soli Nallaseth, MS., Ph.D.&,+3,%

https://actascientific.com/ASMI/pdf/ASMI-04-0792.pdf

Website under construction: Updated on April 17th, 2022

Website Manager: Ferez S. Nallaseth, MS, PhD Founding President, CSO & CEO

Email address: FerezNallaseth@LifeSciencesInstituteNJ.com