THE LSINJ WEBSITE HAS BEEN SUBJECT TO A SERIES OF CYBERATTACKS. VANDALISM OF THE VIDEOS ON THIS WEBINAR PAGE WAS THE LATEST EXAMPLE. 

AS OF JUNE 22nd 2022 ALL FILES ARE FUNCTIONALLY RESTORED. THEY REPRESENT INFORMATION THAT IS NOT ONLY SCIENTIFICALLY SIGNIFICANT BUT ALSO REPRESENTATIVE OF THE HISTORY OF OUR CONTRIBUTIONS TO THE PUBLIC INTEREST. AS WELL AS BEING REVELATORY OF ISSUES FAR BEYOND SCIENCE. WE HAVE INVOKED  CYBER LAW REGULATED BY APPROPRIATE INTERNATIONAL AND FEDERAL AGENCIES. 

WE APOLOGISE FOR THE INCONVENIENCE TO THOSE WHO MAY HAVE VISITED THIS PAGE AND ARE INTERESTED IN OUR WORK.

(I) WEBINAR SCHEDULE: 2019 - 2021

(II) WEBINAR SCHEDULE 2021 - 2022 cycle of Webinars and Meetings (monthly webinars and trimonthly Administrative Meetings)

(I) WEBINARS DELIVERED 2019 - 2021

(6) BioViva CEO Elizabeth Parrish; Webinar August 31st 2019 

Title: Creating Human Health span And Longevity Through Gene Therapy 

Abstract

Biotechnology is at a critical point, comparable to the exponential growth of IT technology in past decades. If we grasp the opportunity, biotech offers a new, attractive engine of growth and vital solutions to today’s biggest challenges. Despite early setbacks, gene therapy and gene editing are finally achieving wider public interest and investment - offering a permanent cure for diseases once believed incurable. With AAV, Lentivirus and now gene editing in over 140 clinical trials the world is on the cusp of a revolution. Alongside traditional gene therapy comes gene editing CRISPR-Cas9 was named the technological breakthrough of the year in 2015, gene editing technologies are now being used in a growing number of clinical trials worldwide; the first human CRISPR trials are now being conducted in all over the world.

 As our technology matures, our approach to medicine must also mature; moving beyond treating individual diseases to a preventative, precise treatment model designed for each individual. Evolving diagnostic and prognostic technology is now expediting the clinical trial process by enabling affordable N=1 trials that provide us with essential safety and efficacy data, fast - helping treatment arrive at the clinic quicker than ever before. Treating age-related diseases such as cancer or cardiovascular disease alone is also an ineffective and inefficient use of resources. We must begin targeting the aging process itself, and BioViva is attempting to do exactly that by pioneering bold, cutting-edge medical solutions. Gene therapy must evolve to become genomic therapy; creating a world in which we achieve precise control of our genome and optimise human health while ensuring healthy, productive longevity for all society. 

Biosketch 

Elizabeth Parrish is the Founder and CEO of BioViva USA Inc., the first company to apply a safe dual gene therapy to a primary mechanism of aging (telomere shortening) in a human patient. Along with her team of medical doctors and PhD scientists, her goal is to make healthy longevity available to all. Elizabeth is campaigning for essential regulatory change and disruptive new business models to expedite the translation of research breakthroughs into the clinic for those in need today. She has held business administration roles at biotech and software companies, and is the owner of Biotrove Investments. She serves on the board of the Regenerative Technology Alliance and a founder of the International Longevity Alliance. Her activities are reflected in major media publications around the world, including making the list of the top 100 most influential people in the world of drug development and manufacture.

(7) Prof. Hafiz Yahya, PhD; October 12th, 2019

Avian Diversity In India

Hafiz Yahya, PhD, Life Sciences Institute of New Jersey, Belle Mead, NJ 08502; Dean, Faculty of Life Sciences; Professor, Dept. of Wildlife Sciences, A. M.U Aligarh – India; Member, Higher Education Group, 12th Five Year Plan, Government of India

Abstract

Spirit of avian conservation and appreciation is deeply rooted in Indian culture and ethos. Many ancient folklores, paintings and sculptures provide illustrative accounts of how earlier people enjoyed watching, eating, taming, dreaming and even worshiping birds. Considering the importance of biodiversitythe doctrine and philosophy of all regions strongly support it. I have discussed this in detail in my book BIODIVERSITY CONSERVATION ETHICS IN MAJOR RELIGIONS.

Biodiversity conservation and climate change are among the most important contemporary issues facing humankind. There is a pressing need to tackle these issues with utmost sincerity by biologists, nature conservatisms, developmental agencies, religions clergies as well as politicians; otherwise thehumankind would jeopardize its own existence on this planet. 

Owing to diverse bio-geographical and  climatological regimes, India is bestowed with a very rich biodiversity and is rightly considered as one of the twelve Mega-biodiversity zones of the world;comprising of 446 Important Bird Areas that supports occurrence of about 1300 species (out of 10065 species world over). Although Carl Linnaeus (1664)had also mentioned some Indian birds in his system of Binomial nomenclature, the scientific documentation of Indian birds started with the invent of British in India. Thus India has a history of  over three centuries old ornithology. Several British Army, Medical and Civil Officers were keen naturalists and maintained well documentations of our flora and fauna. A. O. Hume (1888), the founder of Indian National Congress is also considered father of Indian Ornithology. The eleven volumes of journal Stray Feathers edited by him is a landmark in documentation of Indian birds. The revised edition of Birds of Indian Empires in four volumes and three volumes of Modification of Birds of Indian Empires by StuartsBaker(1922 - 1930) are other very valuable publications. Based on Baker’s, Salim Ali and S. Dripple (1964-1972) published ten volumes of Handbook of Birds of India and Pakistan thatcan be considered to be the Bible of Indian Ornithology. Salim Ali’s life and work has had a remarkable influence on the conservation and propagation of avian study and due to his lifetime patronage birds became a ‘Flagship’ of nature conservation movements in India.  Publication of his book, The Book of Indian Birds by Salim Ali (my Ph.D. supervisor), first published in 1941 and 14th enlarged and revised edition in 2006, remains a milestone for amateur bird watchers and students of ornithology. This book made a great impact even on some politicians. PunditJawaharlal Nehru, the first Prime Minister of India, sent a copy of this book to his daughter Indira Gandhi on her 7th birth day while he was imprisoned in Allahabad Jail. Consequently all three Prime Ministers of India from the Nehru family had a great love for nature conservation. 

Despite a glorious past, due to gradual decline in the quality and content of most of the wildlife habitats, the future of India’s wildlife, vis-à-vis birds, is far from secure. Environmental degradation, more notably the decline and fragmentation of forest cover in India is perhaps the most damaging factor for jeopardizing the sustainability of our faunal and floral heritage. Indiscriminate use of pesticides and insecticides and ineffective implementation of wildlife protection laws, and other anthropogenic pressures are adversely affecting the avifauna of the country.  On a rough estimate, over hundred species of Indian birds are struggling under various categories of endangerment, while the future of the rest is also insecure. While population of vultures has crashed alarmingly, and that too within a very short period of time,the population of common birds like house sparrows, parakeets, baya weaver birds, etc., are also declining. Though the reduction in birds’ population is perhaps a global phenomenon, we need to discuss this issue more seriously as India’s economy is largely based on agriculture and horticulture and birds play vital role in cleansing the insects and rodent pests from the field and orchards. The birds do damage the products to some extent at times, but in the words of Late Dr. Salim Ali this issue could be considered as ‘laborer’s hire’. Besides various economic benefits and food value, the ecological services birds render is of immense value.

In the post globalization development plan of India large tracts of natural habitats are being converted to agricultural and urban landscapes. The demographic and socio-economic factors in these areas have an adverse impact on the spatio-temporal dynamics of bird community and habitat. Hence biodiversity conservation in urban landscapes is also important.Because in the event of vanishing forests home gardens and parks can sustain and develop ecological complexity to the extent that they can provide necessary biodiversity and ecosystem services across the tropics. Further, the importance of urban parks within the cities is highlighted as hotspots for biodiversity.  Park size accounts for the high indicators of species diversity but fragmentation is detrimental for the populations of resident bird species especially during breeding season. As increasing the park size within cities is not achievable, habitat diversity can be increased along with resource availability by adding nest boxes, bird feeders and bird baths to the parks. Official policy making, research and awareness are other key factors.

In addition to various conservation measures prevailing in the country, we ought to emphasize the importance of education and awareness more elaborately and effectively. There is an urgent need to identify areas of gaps even in the regime of research and management of Indian birds. This is also true for the conservation of other wildlife species. Several recent exercises, including preparation of National Biodiversity Action Plan (NBAP), cleaning of Ganges, Project tiger, etc., have so far not yielded the desired results. An analytical scientific approach is needed to formulate policies to balance the country’s development initiatives and nature conservation programs. The mad rush of unsustainable development may endanger both: biodiversity on which the mankind depends so heavily, as well as the future of a healthy environment which is imperative for the survival of nature as well as the Homo sapiens.   

(8) Dr. Alex Diaz, Ph.D.; Webinar November 11th, 2019

Sports Mental Edge, New York, NY & Life Sciences Institute of New Jersey, Belle Mead, NJ 08502

Title: Merging Interoceptive Knowledge with Peak Performance in Sports

Abstract

The workshop aims at educating participants about interoceptive knowledge, its clinical implications, and its relevance in sport performance.

Interoceptive awareness brings attention to the felt sense of our bodies as a conduit to elicit implicit memory. These memories lead to both, pleasant and uncomfortable body sensations, which are the body’s non-verbal manifestation of thwarted fight, flight, or freeze responses.  When individuals are exposed to high levels of stressful experiences, our organic nervous system engages into an autonomic physiological responses for the purpose of remaining safe (Siegel, 1999). Under the impossibility to engage survival fight/flight responses, these bodily stored incomplete responses are again relived when the individual’s sensory awareness perceives a new threat that resembles that of the original stressful episodes (Pollatos, Kirsch, & Schandry, 2005). Under the impossibility to organically complete thwarted responses, a compromised nervous system develops, leading to patterns of unhealthy behaviors (Cozolino, 2006). Anger, high levels of anxiety, smoking, drinking, and disordered eating become the body’s way to navigate a compromised organic state (Levine, 1997).

The workshop will explain the neuroscience behind human physiology and how its compromised instinctual responses may create havoc and repeated unhealthy patterns (Pennebaker, 1983). The workshop will combine lecture on neuroscience and interoceptive psychology, and provide experiential exercises to enhance personal self-awareness to regulate emotions and promote peak performance readiness.  

Participants will learn:

1-         Understanding how bi-directional communication between our nervous system and the brain supports the development of emotional regulation to enhance focus;

2-         Explain Polyvagal Theory: It will explain how our bodies’ neurological mechanisms regulate social engagement, and fight, flight and freeze responses. This theory explains an athlete’s normal physiological stressful responses that can become habitual patterns, such as choking under pressure, impulsive behaviors, compromised digestive system (throwing up), headaches, and many other bodily symptoms;

3-         It is not what we “see”, but what we “perceive.” The brain’s way to assess the environment may go against what the athlete “believes” it really is;

4-         Use felt-sense awareness exercises to better assist athletes regulate their own emotions, so the become more empowered by knowing and using their own implicit body knowledge rather than developing dependency on external emotional regulators, which are oftentimes unhealthy options;

5-         Understanding the “Window of Tolerance,” a range of physiological equilibrium that promotes focus and grounding to achieve “in the zone” performance;

The workshop will provide research-based knowledge about how we can embrace our body sensations for the purpose of self-regulation and enhanced focus (Rothschild, 2000), which are key traits in achieving peak performance. Invididuals are used to attending to their bodies when they feel pain or discomfort, but bodies also manifest positive felt-sense experiences (Mehling et al., 2009). In fact, these positive felt-sense experiences are the neurological foundation for self-regulation (Levine, 1997). By providing an educational explanation of brain functioning, theories, and experiential exercises, participants will greatly understand at a much deeper level the wisdom of our bodies and how we can capitalize to manage and expand self-regulation (Siegel, 1999).

An athlete’s dysregulated nervous system has been accounted for unhealthy choices (Cogan, 2005). As the nervous system is attempting to self-regulate, its compromised hyperarousal or dissociation stuck state seeks outside “helpers” to bring emotional homoeostasis (Rothschild, 2000). Unfortunately, these unhealthy choices can become detrimental habits and, consequently, potential concerns for the athletes’ overall health. 

More than ever before, athletes are under highly stressful competitive demands as competition is reaching unseen levels (Weinberg & Gould, 2011). Although improvements in physical training, skills, and nutrition have greatly contributed to enhancing achievement, the mental component greatly determines how to sustain focus when it matters most (Weinberg & Gould, 2011). To that end, a physiologically organic coping skill, such as interoceptive awareness, provides a source of self-knowledge that teaches athletes to attend to their implicit language that serves to not only as a tool to manage emotions in competition, but also as a life skill resource.  

References

Cogan, K. D. (2005). Eating Disorders: When rations become irrational. In S. Murphy (Ed.). The sport psych handbook (pp.237-253). Champaign, IL: Human Kinetics

Cozolino, L. (2006). The neuroscience of human relationships. New York, NY: Norton.

Levine, P.A. (1997). Waking the tiger. Berkeley, CA: North Atlantic Books. 

MacLean, P.D. (1993). On the evolution of three mentalities. In J.B. Ashbrook (Ed.). Brain, culture & the human spirit: Essays from an emergent evolutionary perspective (pp. 15–44). Lanham, MD: University Press of America.  

Mehling, W.E., Gopiseetty, V., Daubenmier, J., Price, C., Hecht, F.M., & Stewart, A. (2009). Body awareness: Construct and self-report measures. PloS ONE, 4(5), 1–18.

Pennebaker, J.W. (1983). Implicit psychophysiology: Effects of common beliefs and idiosyncratic physiological responses on symptom reporting. Journal of Personality, 51(3), 468–496. 

Pollatos, O., Kirsch, W., & Schandry, R. (2005). On the relationship between interoceptive awareness, emotional experience, and brain process. Cognitive Brain Research, 25, 948–962. 

Porges, S. (2008). The polyvagal theory: New insights into adaptive reactions of the autonomic nervous system. Cleveland Clinic Journal of Medicine, 75 (Supplement X), 81–85. Retrieved from http://www.lifespanlearn.org/documents/Porges%20Polyvagal%20Theory.pdf Price, C.J., & Thompson, E.A. (2007). Measuring dimensions of body connections: Body awareness and bodily dissociation. Journal of Alternative Complementary Medicine, 13(9), 945–953. 

Rothschild, B. (2000). The body remembers: The psychology of trauma and trauma treatment. London, UK: Norton.

Siegel, D.J. (1999). The developing brain: How relationships and the brain interact to shape who we are. New York, NY: Guilford Press.

Weinberg, R., & Gould, D. (2011). Foundation of Sport and Exercise Psychology. Champaign, IL: Human Kinetics

(9) Dr. Nirmali Wijegoonawardana, Ph.D.; Webinar January 1st, 2020

LSINJ BM: CHABMR (Chief Historian & Archivist for Biomedical Research) Primary External External Affiliation: Historian, Senior Lecturer and Head, Department of History, University of Colombo, Colombo, Sri Lanka (Ceylon) (2015 – present) 

Title: Medicinal plants in Sri Lanka: A review ! 

Abstract

A principle question of the modern world today has been the true efficacy of medicinal plants and herbal products. Millions of people around the world are affected by neurodegenerative diseases such as dementia, Alzheimer disease and Parkinson disease. It is estimated that 15% of the population in western countries are affected by one of these diseases. Despite many advances in the field of medicine no remedy is available yet to combat the situation. Treatment with enzyme inhibitors such as acetylcholine esterase only gives temporary relief. Many herbs are known to contain these inhibitors naturally along with hundreds of other beneficial constituents. They can either prevent the onset of these degenerative diseases or slow down progress of the condition. Consequently resulting in an exponential increase in the employ of medicinal plants in technologically advanced societies has ensued in multiple drugs and key chemotherapy products being acquired and contrived through the use of medicinal plants. Sri Lanka is known for its plethora of biodiversity with numerous plant resources. Vast majorities of the plants found in Sri Lanka have medicinal properties in them and thus have the potential to be used as medicines to treat many heath diseases. Medicinal plants have already been employed as mechanisms of treatment in Sri Lanka. Some of the traditional methods of Sri Lankan medicinal practices comprise of Ayurveda, Unani and Deshiya Chikitsa, where plants are used as tools for remedies of diseases. Some of the medicinal plants in Sri Lanka offer a more practical usage such as plants with rich sources of antioxidants, which help prevent and delay various diseased conditions. A prime example of this is the Curcuma longa, popularly known as turmeric or Indian saffron. Originating from South Asia and cultivated in India, Sri Lanka, China, and Java. Reputed for a wide range of medicinal uses in Ayurveda. The Rhizome of this plant is used for medicinal purpose. Asians use the powder of the rhizome of this herb in preparation of curries. Low occurrence of neurodegenerative diseases among Asians (2%) has been attributed to regular consumption of turmeric by way of curries. Curcumin is regarded as the main active constituent. Sri Lankan medicinal techniques employ the use of the entire plant including the leaves, roots, fruits, flowers and bark to treat symptoms of disease. For instance, the Popular Clove oil is extracted from the floral buds of Syzygium Aromaticum which are subsequently used for the cure of toothache as Clove oil has both antibiotic and antiseptic properties. Therefore, this study will provide overview of herbal plants used in the traditional medicinal practices of Sri Lanka. 

(10) VP Ralph Sherman, B.S.; Webinar February 8th, 2020

LSINJ BM: Vice President & Chief of Biophysics Operations; Chief of Technology Transfer Operations; Chief of Electronics Operations; Chief of Biophysics Technology Transfer - Central Nervous System (EEG) Thermodynamics; Group Leader in Groups on Biophysics, Electronics and Technology Transfer Operations; Member Group on Neurosciences, Neuropathology, Neuropsychiatric Diseases, Experimental Psychology, Anoxia Tolerance, Thermodynamic States of Hypoxic Neurophysiological Systems 

Primary External External Affiliation: Biophysics Technology Transfer - Central Nervous System (EEG) Thermodynamics, Myrtle Point, Oregon, USA (2004 - Present) 

Title: Transition State Theory (TST): Sodium (Na+) transport in Alzheimer's Disease.

Abstract

Transition State Theory

I have 40 posts on Slide Share.  I use them like an old time “Scrap Rook of Memories.”  Some of them are related to my study of Transition State Theory. Here is image number 12 from my reinterpretation of data regarding neuronal sodium transport in Alzheimer’s disease.  

https://www.slideshare.net/ralphsherman33/least-action-parametric-quantification-of-ad-na-k-atpase-in-ee-compensation

 From my LinkedIn Profile:

 Seeking collaboration studying the quotients: G/k and G/S as derived from Transition State Theory. G/k has the dimension Action per mol per mol. G/S has the dimension Temperature (Kelvin). I call the quotients Gibbs Molar Action and Temperature Quotient. I assume that they are key measurable parameters of the TST Activated Complex.

http://www.slideshare.net/ralphsherman33/transition-state-theory-eeg-alpha-rhythm

http://www.slideshare.net/ralphsherman33/gibbs-molar-action-29061607

http://www.slideshare.net/ralphsherman33/temperature-quotient-tst

 ---------------------------------------------------------------------------------------------------------

 I started this project in 1952 when I first learned of the 1936 Arrhenius Plot EEG work of Hudson Hoagland.

I met Hoagland at the Biophysics Meeting in Pittsburg in 1958.  I visited Koella at Ciba in ca. 1980.

 https://www.slideshare.net/ralphsherman33/werner-koella-1954/1

(11) VP Jean Plante, Webinar  March 8th, 2020

Position and Role in LSINJ: Vice President for Bioethics, Philosophy, Neurosciences at the interphase with Biology; Derivation of Medical Equipment similar to (NGPDT).

Member of Working Group in LSINJ and Group Leader: First Working Group: Evolutionary Genetics, Reproductive Biology and Preemptive Medicine consisting of Ferez S. Nallaseth, Ph.D., George Perry, Ph.D., Tony Lai, MD, M.B.B.S., FACOG and Liz Parrish, CEO/CMaO) (Co-Group Leaders: Ferez S. Nallaseth, Ph.D. and Tony Lai, M.D., M.B.B.S. and FACOG; Second working group: Co - Leader of Group for Pharmaceutical Liaison – Developing Societies; Third working group: Member of Group for Public Science Education in Developing Societies consisting of George Perry, Ph.D., Dr. Alex Diaz, Kholis Audah, Ph.D., Tony Lai, M.D., Hafiz S. Yahya, Ph.D., Ferez S. Nallaseth, Ph.D., Syed M. Ahmed, Ph.D. Liz Parrish, CEO/CMO and Nirmali Wijegoonawardana, Ph.D. (Co-Group Leader with others; International representation: U.S.A., India, Pakistan, Jamaica, India and Sri Lanka).

External affiliations: Consultant/coordinator for NGPDT 

Title: ‘REALITY and, our reality’ 

Abstract

An interactive conference/webinar.

Multiple topics considering partially explaining today's so-called modern world. 

Articles under where you can read some notion of so-called empirical science!

Topics cover medicine, mental health and today (‘s) generalize health problems directly linked to our lifestyle. I will go back as far as the beginning of agriculture creating poverty (.) Almost around the globe!

 REALITY versus our reality!

 Before you judge others or claim any absolute truth, consider that…

… you can see less than 1% of the electromagnetic spectrum and hear less than 1% of the acoustic spectrum. As you read this, you are travelling at 220 kilometres per second across the galaxy (.) 90% of the cell in your body carry their own microbial DNA and are not « YOU ».

The atoms in your body are 99.9999999999999999% empty space and none of them are the ones you were born with, but they all originated in the belly of a star. 

 Human beings have 46 chromosomes, 2 less than the common potato. The existence of a rainbow depends on the conical photoreceptors in your eyes; (for) the animals without cones, rainbows do not exist. So you don’t just look at the rainbow, you create it. This is pretty amazing, especially considering that all the beautiful colours (that) you see represent less than 1% of the electromagnetic spectrum!

 "Writing with characteristic verve, Diamond’s “Worst Mistake in the History of the Human Race” summarizes an impressive amount of material in just three pages. At the top of the second and third pages, he headlines the main point: “The adoption of agriculture, supposedly the decisive step to a better life, was in fact catastrophic. With agriculture came the curses of social and sexual inequality, disease, and despotism” (1987, 65-66)."

 https://www.livinganthropologically.com/archaeology/agriculture-worst-mistake/

 https://current-oncology.com/index.php/oncology/article/view/5165/4289

 https://pdfs.semanticscholar.org/315e/5d7d15c8470bc00e0fbd00ecb8ebe2158e25.pdf

(12) BM Neuroscientist Sina Varmaghani, M.S., Webinar May 2nd, 2020

Position and Role in LSINJ: Board Member and Group Member of Engineering, Cognition, Neuroscientific, Computational and Gaming Groups, Interests: Perception, Visual-Spatial cognition, Cognitive linguistics, Depression.

Member of Working Group in LSINJ : Sina Varmaghani, M.Sc., Director and Liaison with Scientific Institutions in Iran; Neurosciences, Neuropsychiatry, Neurophysiology and Psychology, Thermodynamics of Neural Functions under Hypoxic Conditions, Stroke and Ischemia in Anoxia Tolerant Turtle brains, Mutational Basis of Brain Cancers and Neurodegenerative Diseases - George Perry, Ph.D., Adam Bogart, Ph.D., Ralph Sherman, B.S., Alex Diaz, Ph.D., Ferez S. Nallaseth, Ph.D. & Sina Varmaghani, MSc (Group Leader – George Perry, Ph.D.); Engineering and Construction Ralph Sherman, B.S. and Syed M. Ahmed, Ph.D. (Group Leader); Neuropsychiatric diseases, neuroimaging and MRI modeling of neuropsychiatric diseases; Neurodegeneration and Aging. Radiology and statistical analysis of brain metabolites during normal aging and pathological animal models of Neurodegenerative Disease under conditions of caloric restriction, George Perry, Ph.D., Adam Bogart, Ph.D., Ralph Sherman, B.S., Alex Diaz, Ph.D., & Ferez Nallaseth, Ph.D. & Sina Varmaghani, M.Sc. (Group Leader – Adam Bogart); Adam Bogart, Ralph Sherman B.S. and Sina Varmaghani, M.Sc. Group on Statistical and Mathematical Operations (Group Leader - Adam Bogart, Ph.D. (CISMO – Chief of Statistical & Mathematical Operations); Groups on Biophysics, Electronics and Technology Transfer Operations, Ralph Sherman, B.S., Adam Bogart, Ph.D., Syed M. Ahmed, Ph.D., George Perry, Ph.D., & Sina Varmaghani, M.Sc., (Co-Group Leaders, Ralph Sherman, B.S., Adam Bogart, Ph.D. & George Perry, Ph.D.).

External affiliations: Department of Psychology, University of Isfahan, Iran; Electronic Engineering, Faculty of Engineering, Urmia University, Iran.

Title: A pathological review on spatial memory

Abstract

Knowing where one is, where resources are, and how to get to safety are some of the most fundamental and important challenges faced by all animals. When specified formally, these challenges seem to be exceedingly complex; yet they are routinely performed by even the simplest organisms and the most absent-minded people. Moreover, these basic abilities are typically prerequisites for other more complex behaviors. Spatial cognition is a branch of cognitive science that seeks to understand how humans and other animals perceive, interpret, mentally represent, and interact with the spatial characteristics of their environment. Nearly all behavior has spatial consequences, and many of the psychological processes that underlie behavior have spatial content. A basis for organizing the field of spatial cognition recognizes a primary distinction between cognition that is needed for interaction with one’s immediate environment and cognition that is based on stored knowledge about space. This approach essentially organizes space temporally into (a) online structures and processes that handle dynamic transient spatial information and (b) offline structures and processes that encode, store, and retrieve spatial information over the long term. The distinction between online and offline treatment of spatial information parallels the distinction between perception and memory in the general cognitive literature. Online spatial processes enable an organism to situate itself in the present moment and to interpret and use spatial relationships such as distances and directions to achieve immediate goals. Offline spatial processes involve the long-term encoding, storage, and retrieval of spatial information and enable complex behaviors such as navigation, route planning, and direction giving. In this presentation the characteristics of Offline spatial processes and in particular spatial memory, its associated brain regions, disorders, and drugs affecting spatial memory will be discussed.

(14 repeat 11) VP Jean Plante, Webinar  June 20th, 2020

Position and Role in LSINJ: Vice President for Bioethics, Philosophy, Neurosciences at the interphase with Biology; Derivation of Medical Equipment similar to (NGPDT).

Member of Working Group in LSINJ and Group Leader: First Working Group: Evolutionary Genetics, Reproductive Biology and Preemptive Medicine consisting of Ferez S. Nallaseth, Ph.D., George Perry, Ph.D., Tony Lai, MD, M.B.B.S., FACOG and Liz Parrish, CEO/CMaO) (Co-Group Leaders: Ferez S. Nallaseth, Ph.D. and Tony Lai, M.D., M.B.B.S. and FACOG; Second working group: Co - Leader of Group for Pharmaceutical Liaison – Developing Societies; Third working group: Member of Group for Public Science Education in Developing Societies consisting of George Perry, Ph.D., Dr. Alex Diaz, Kholis Audah, Ph.D., Tony Lai, M.D., Hafiz S. Yahya, Ph.D., Ferez S. Nallaseth, Ph.D., Syed M. Ahmed, Ph.D. Liz Parrish, CEO/CMO and Nirmali Wijegoonawardana, Ph.D. (Co-Group Leader with others; International representation: U.S.A., India, Pakistan, Jamaica, India and Sri Lanka).

External affiliations: Consultant/coordinator for NGPDT 

Title: ‘REALITY and, our reality’ 

Abstract

An interactive conference/webinar.

Multiple topics considering partially explaining today's so-called modern world. 

Articles under where you can read some notion of so-called empirical science!

Topics cover medicine, mental health and today (‘s) generalize health problems directly linked to our lifestyle. I will go back as far as the beginning of agriculture creating poverty (.) Almost around the globe!

 REALITY versus our reality!

 Before you judge others or claim any absolute truth, consider that…

… you can see less than 1% of the electromagnetic spectrum and hear less than 1% of the acoustic spectrum. As you read this, you are travelling at 220 kilometres per second across the galaxy (.) 90% of the cell in your body carry their own microbial DNA and are not « YOU ».

The atoms in your body are 99.9999999999999999% empty space and none of them are the ones you were born with, but they all originated in the belly of a star. 

 Human beings have 46 chromosomes, 2 less than the common potato. The existence of a rainbow depends on the conical photoreceptors in your eyes; (for) the animals without cones, rainbows do not exist. So you don’t just look at the rainbow, you create it. This is pretty amazing, especially considering that all the beautiful colours (that) you see represent less than 1% of the electromagnetic spectrum!

 "Writing with characteristic verve, Diamond’s “Worst Mistake in the History of the Human Race” summarizes an impressive amount of material in just three pages. At the top of the second and third pages, he headlines the main point: “The adoption of agriculture, supposedly the decisive step to a better life, was in fact catastrophic. With agriculture came the curses of social and sexual inequality, disease, and despotism” (1987, 65-66)."

 https://www.livinganthropologically.com/archaeology/agriculture-worst-mistake/

 https://current-oncology.com/index.php/oncology/article/view/5165/4289

 https://pdfs.semanticscholar.org/315e/5d7d15c8470bc00e0fbd00ecb8ebe2158e25.pdf

(15) Dr. Ferez S. Nallaseth, MS, PhD, Webinar August 1st 2020

Position and Role in LSINJ: Founding President, Chief Executive Officer (CEO), Chief Scientific Officer (CSO), Chief Financial Office (CFO) & Principal Donor; 

Member of Working Group in LSINJ: (section in this website on Board Members)

External affiliations:  (section in this website on Board Members)

Title: Morphogenesis of skin in 3D co-cultures - sorting and mixing of interspecific, intra-specific, differentiated and stem cells traced with lineage specific keratins.

Abstract:

In mouse models Inter-follicular Epithelial (IFE) and Hair Follicle (HF) stem cells exclusively yield the epithelial layer under homeostasis and wound healing conditions. In vitro studies in 3D were initiated due to regulatory constraints and functional differences between murine and human skin. Combinations (12) of intraspecific, interspecific, primary, established, differentiated and stem cells were analyzed by 4 approaches. In hanging drop (HD) cultures, cells have the same opportunity to interact as they would in vivo. Published HD methods were extensively adapted to the analysis of skin morphogenesis which at least initially followed constraints imposed by the Differential Adhesion Hypothesis (DAH). HD aggregate formation displayed serum and cell type dependent spectrum of demixing behaviors. At equilibrium, human dermal cells and keratinocytes completely demixed from each other, thus exhibiting very low to non-existent levels of cross-adhesion possibly required for boundary formation. However, demixing of other interspecific and stem cell combinations was more variable even at equilibrium. This contrasts with embryogenesis when the differentiation of the single cellular embryonic epithelium is obligatorily dependent on contact with the underlying mesoderm in initiating the morphogenesis of skin. In Human Skin Equivalents (HSEs) morphology, with exceptions e.g. HF, but not morphogenesis, recapitulates in vivo skin. However, in 2D gel electrophoresis, proteins extracted from HSEs displayed differentiation stage specific mobility of keratins. In contrast in 2D co-cultures of HDFn and rat stem cells exhibited highly variable distributions, which were more consistent with isotypic affinities of cell types. These differences may identify a requirement for additional components for in vivo morphogenesis of these cell types into skin. Whether transient contact induces expression of HF, IFE and SC specific epitopes of keratin in all 3D cultures is being established.

(16) Dr. Ferez S. Nallaseth, MS, PhD, Webinar September 5th 2020

Position and Role in LSINJ: Founding President, Chief Executive Officer (CEO), Chief Scientific Officer (CSO), Chief Financial Office (CFO) & Principal Donor; 

Member of Working Group in LSINJ: (section in this website on Board Members)

External affiliations:  (section in this website on Board Members)

Title: Comparative evolutionary analysis of the neurophysiological and molecular basis of anoxia resistant turtle and hypoxia sensitive mammalian brains to identify oxygen responsive targets in neurodevelopment

Abstract 

In mammalian brains, hypoxia is lethal within five minutes but turtle brains (Trachemys scripta) can recover from 24 hours of anoxia. Genes previously studied in hypoxic mammalian brains and regulating immediate-early responses, heat shock, apoptosis, mitochondrial biogenesis, respiration, vasculogenesis and angiogenesis were examined in normoxic, hypoxic and anoxic turtle brains. High-stringency annealment of turtle gDNA with mammalian (mouse, rat, human) probes followed by sequence alignments with the turtle genome validated their conservation. One clear candidate supporting hypoxia resistance was elevated levels of Hif1a and Hif1b identified by Northern blots. However, kinetics of the two partners of AP1 RNAs were distinct. Concomitantly HIF1 and AP1 from turtle brain extracts and MDA-231 breast cancer cell extracts bound to and shifted their consensus motifs in EMSAs. In addition to AP-1 binding, upregulation of several anti-apoptosis oncogenes was noted: c-Jun, Bcl2, c-Fos & Hsp70. Unexpectedly Nad5, encoding a protein in complex I of the mitochondrial respiratory chain, was not upregulated at any time point, unlike in cardiac hypoxia. These and other neurophysiological results suggest that, under conditions of limiting energy (ATP) and reducing (NADH) equivalents the evolutionary loss of the ability of mammalian brain to resist hypoxia correlates with its metabolic and ion channel extravagance, in contrast to the conservatism of turtle brain including inhibiting depolarizing channels and stimulating rectifier and inhibitory channels. However, opposing hypoxia responses of dolphins and chimpanzees exclude simple explanations like cognitive acquisitions. These results have implications for human ischemia, neurodegeneration and the Warburg effect. 

Broad Areas of Webinar - including diverse contributions of friends, family, mentors, peers and collaborators

(1)Neurosciences: from basics to selections from the ongoing revolution. From basics, methods, cells, neurons, glia, organelles, energetics, action potentials (AP) to Hyperinteraction & Transcranial Magnetic Stimulation (TMS) for brain to brain (B2B) communications.

(2)Stresses or genotoxic shock & responses to it including in the Brain.

(3)In the response to genotoxic including respiratory stress, the role played by neurons, glial support cells, mitochondria, immune system modulation of the gut-brain axis under conditions of neuronal homeostasis and/or neuropathological conditions.

(4)Our results in ‘Comparative evolutionary analysis of the neurophysiological and molecular basis of anoxia resistant turtle and hypoxia sensitive mammalian brains to identify oxygen responsive targets in neurodevelopment’. How do our results fit into contemporary perspectives in the neurosciences?

(5)Those who fostered in us a sense of the Public Interest or Common Good and ethical compunctions. Reasons for the foundation of our institute the LSINJ, it’s existence, diversity & continued promotion of it’s core mission – preemption of genetic diseases and birth defects.

(17) Dr. Ferez S. Nallaseth, MS, PhD, Webinar October 3rd 2020

OUTLINE OF RELATION BETWEEN WEBINARS 17 & 18

LSINJ Webinar 17 on 3rd October 2020:

Conceptual Foundation of the core mission of the LSINJ in preempting genetic disease lesions:

Switching the paradigm in medicine from managem-ent of genetic lesions & their pathology(s) to preemption!

(I) Foundation of the core mission of the LSINJ in preempting genetic disease lesions emerging from our work on the Evolutionary Genetics of Speciation, Genetic Regulation of Chromosome (Genome) Biology, Sex Determination and Gametogenesis.

(II) Why preemption complements rather than subsumes contemporary approaches translational and precision medicine, including CRISPR/Cas9-Pam, Stem Cell & Gene Therapy?

(III) Published papers - Synopsis Of relevant books in preparation.

LSINJ Webinar 18 on 7th November 2020:  Our data and results in addition to ~100 years of results for the conceptual foundation of the core mission of the LSINJ:

Dissecting physiologically & developmentally relevant genetic regulation of mammalian chromosome biology with murine interspecific backcrosses, Y chromosomes, unstable inverted repeat (IR) in Sxr-regions (spanning Sry loci), sex reversal phenotypes, mammalian Oris, HJ-STR complexes & zDNA.

  (i)         Application of evolutionary genetics of speciation to systematizing, surveilling & controlling chromosome (genome) biology with mouse interspecific genomes x Y chromosomes inducing instability & Y chromosome wide alterations in epigenetic modifications of repetitive sequences, including, in GATA/GACA-rich Sxr-regions (spanning Sry-loci) correlated with dysregulated mouse sex determination & gametogenesis as reporters.

(ii)         Eliciting biochemical, genetic, cellular & molecular mechanisms or factors regulating Recombination-Replication-Repair (RRR) systems in yeast including the HJ – STR complex, mammalian Oris & left handed zDNA sequences.

References:

Shifting the therapeutic paradigm in medicine from post mutational (& pathological) intervention to preemption – a synopsis of the ‘nuts and bolts’ Ferez S. Nallaseth, MS, PhD, MOJ Proteomics Bioinform. 2019;8(2):41‒43.

Is There a Role for an Evolutionary Genetics Based Rational Health Policy In Global Biomedical, Health and Economic Policies? Nallaseth. J. Mol Biol OMIC

What is the Life Sciences Institute of New Jersey? Why and how does it exist? What are its goals? Ferez S. Nallaseth, MS, PhD, Mol Biol OMIC 2015, 4: 3, (2168 - 9547 - 1000130.php?aid=60692)

(17) Dr. Ferez S. Nallaseth, MS, PhD, Webinar October 3rd 2020

Title: Abstract Switching from management of genetic lesions and their pathology(s) to preempting them – a sketch!

Position and Role in LSINJ: Founding President, Chief Executive Officer (CEO), Chief Scientific Officer (CSO), Chief Financial Office (CFO) & Principal Donor; 

Member of Working Group in LSINJ: (section in this website on Board Members)

External affiliations:  (section in this website on Board Members)

Title: Abstract Switching from management of genetic lesions and their pathology(s) to preempting them – a sketch!

Ferez S. Nallaseth, MS, PhD, Life Sciences Institute of New Jersey, Belle Mead, NJ 08502.

Various studies have placed the numbers of disease pathology(s) with either genetic or genetic and environmental etiology as greater than 65% of all evaluated diseases and annual costs of hundreds of trillions of dollars. It is impossible to quantify the neurobiological and social impact of the most intractable and dehumanizing of diseases on individuals, families and communities. For convenience genetic diseases can be clearly delineated into events preceding and following the insertion of their causative genetic lesions into the genome as shown below:

(1) networks of genes maintaining & repairing genomes fail -> (2) insertion of genetic lesion -> (3) disease pathology manifested (only after additional factors are contributed)

We illustrate these points with the recent successful Gene Therapy of Sickle Cell Anemia in humans while contrasting its advantages and disadvantage as well as those of similar therapies. The current paradigm in medicine is based on immediate short term therapeutic intervention e.g. Gene Therapy, which are exclusively restricted to step 3. This is often when, due to the intractable nature of the disease, it is too late. Most of the fundamental and defining work on genetic mechanisms from step 1 leading to step 2 is done in simple Model Organisms where the necessary scientific basis and technical methods are available. However, by themselves none of these results and methods can lead to preempting step 2 in humans.

Step 2 occurs when genes for maintenance or repair of specific target genes (or general groups of sequences, loci, chromosomes and genomes) with which they are co-evolved are uncoupled or fail to function. Mechanisms and components collectively inserting mutations in the genome constitute the Mutome. Elucidating the failure of co-evolved genes and so the molecules, mechanisms, and processes leading to step 2 requires a relevant system for generating them. This system emerges from a well-established principle governing evolutionary genetics of speciation. Namely that when genomes of 2 species A and B are combined by mating into an interspecific genome A + B in the lab or field the frequencies of a broad spectrum of genetic lesions underlying several traits are significantly elevated.

Species A x Species B -> A + B genome -> (high frequency/broad spectrum) genetic lesions

This result is illustrated by our work on the destabilization of the mouse Y chromosome, its sex determining region (Sxr) and gene/locus (Sry) by combining them with interspecific genomes (Nallaseth, 1992; Nallaseth and Guo, 2011; Nallaseth et al, 2012, 2016). The genetic lesions underlying an array of traits such as sterility, inviability, XY female sex reversal, coat color variation and anemia may reveal associated lesions identified by ‘panning’ with methods of low level resolution. This contrasts with conventional high resolution targeting and selection of mutant phenotypes which do not reveal the serendipitous processes underlying the insertion of genetic disease lesions.

The application of this principle first in the Discovery Phase and then in the Analytical Phase with the power of high resolution contemporary methods allows the identification of relevant genetic networks, molecules and mechanisms failing in step 1 and leading to step 2 which together constitute the Combinatorial Approach surveilling and controlling the Mutome. For conceptual, scientific and technical reasons the mouse is the Model Organism of choice for initiating these studies. The emergent results can then be transposed to and applied in humans. The Combinatorial Approach depends on the application of a wide spectrum of principles and methods. In the Discovery Phase these include the application of lower to midlevel resolution with principles and methods of evolutionary genetics of speciation, SNPs, Haplotype Maps and Comparative sequencing. Arrays of defined mouse genomes and classical genetics can identify linkages structural and functional relationships of dysfunctional genes and loci with increasingly greater resolution using feral species, Inbred Strains, Consomic Strains, Recombinant Inbred Strains, Collaborative Cross Strains, etc... Informed by the specific nature of lesions identified in the Discovery Phase higher resolution methods of analyses can be incorporated into the Analytical Phase. They include, physico-chemical-biology, nanoscale to attoscale processes and sensors, OMICs, Mass Spectra, optonics, photonics, spectronics, laser/atomic tweezers, graphene biosensor applications, 3D cultures of spheroids/organoids, radiowaves, wireless, fibre optics, Artificial Intelligence and supercomputers. A broad schematic diagram or a Flow chart of this overview of the Combinatorial Approach could be:

(1)PREPARATIVE ORGANIZATIONAL PHASE <-> -> (2) INITIATION OF PARALLEL AND MULTIDIRECTIONAL DISCOVERY PHASE (MICE) <-> -> (3) SUPER-COMPUTATION <-> -> (4) OVERLAPPING, PROGRESSION INTO, PARALLEL AND MULTIDIRECTIONAL ANALYTICAL PHASE <-> -> (5) SUPER-COMPUTATION <-> -> (6) OPERATIONAL PHASE IN MICE (7) TRANSLATION OF RESULTS AND SYSTEMS TO HUMANS <-> -> (8) SUPER-COMPUTATION <-> -> (9) OPERATIONAL PHASE IN HUMANS <-> -> (10) PREEMPTION OF GENETIC DISEASE LESIONS.

These steps will lead to the systematization, surveillance and control of the networks of genes maintaining and repairing the human genome in real time which is required for preempting genetic disease lesions in humans. It will bring the indispensable shift in the current paradigm in medicine from post mutational management of pathology to preemption of diseases. Although the scientific, technical, conceptual, ethical and economic challenges facing the Combinatorial Approach are daunting they are not insurmountable. It is the Culture of Science that remains the single most significant barrier to even initiating this endeavor with all the enormity of its impact for the Public Interest. The underlying and implicit principles of unknown variables, scale, scope, dynamics, and nature, non-targeting and imprecision of the Combinatorial Approach are reflected in other similarly large undertakings that are resolved by Artificial Intelligence and supercomputers and that are currently underway. These include (1) next generation sequencing (NGS) and mapping of Connectomes of the Brain in the Life Sciences, (2) the discovery of Sub-atomic Particles in Particle Accelerators (e.g. Fermi Accelerators and the Large Hadron Collider) in the Physical Sciences, and (3) the exploration of Space.

Report and Recordings:

(18) Dr. Ferez S. Nallaseth, MS, PhD, Webinar 18, November 14th 2020

Title: Systematization of the regulation of mammalian chromosome biology with evolutionary genetics & OMICs: A synopsis.

(Dissecting physiologically & developmentally relevant genetic regulation of mammalian chromosome biology with murine interspecific backcrosses, Y chromosomes, unstable direct and inverted repeat (DR & IR) sequences in ~200 kb Sxr-regions (spanning Sry loci), sex reversal phenotypes, mammalian Oris, HJ-STR complexes & zDNA structures.) 

Position and Role in LSINJ: Founding President, Chief Executive Officer (CEO), Chief Scientific Officer (CSO), Chief Financial Office (CFO) & Principal Donor; 

Member of Working Group in LSINJ: (section in this website on Board Members)

External affiliations:  (section in this website on Board Members)

Position and Role in LSINJ: For more on Dr. Ferez S. Nallaseth, see the attachments and visit the LSINJ BM section on the site: https://www.lifesciencesinstitutenj.com/board-members, https://sites.google.com/site/nallasethfs/home/pdf-documents , https://www.researchgate.net/profile/Ferez_Nallaseth as well as his Profile on LinkedIn: https://www.linkedin.com/today/author/ferez-soli-nallaseth-m-s-ph-d-3112a714 

Interests:  Core Areas: Evolutionary Genetics of Speciation inducing dysfunctional regulation of Chromosome and Genome Biology; DNA recombination; DNA replication; Sex Determination; Speciation; Ancillary Areas: Neurophysiological and molecular basis of anoxia resistance in turtle brains; Structure/function and expression of Proteins from heterologous hosts; Multi-cue induction of skin morphogenesis in vitro; Overview in Life Sciences: Genetics (Somatic Cell, Mitochondrial, Yeast and Mouse (Epigenetics), Biochemistry and {Molecular, Stem/Cellular, Developmental, Cancer, Chromosome/Genome, Structural, Reproductive (Sex Determination and Gametogenesis) and Evolutionary (Speciation, Protein/Nucleotide Divergence)} Biology, Neurobiology, Virology and Microbiology (Microbial - Evolution, Ecology, Genetics).

Title Systematization of the regulation of mammalian chromosome biology with evolutionary genetics & OMICs: A synopsis.

Abstract 

(Dissecting physiologically & developmentally relevant genetic regulation of mammalian chromosome biology with murine interspecific backcrosses, Y chromosomes, unstable direct and inverted repeat (DR & IR) sequences in ~200 kb Sxr-regions (spanning Sry loci), sex reversal phenotypes, mammalian Oris, HJ-STR complexes & zDNA structures.)

(i)                  Application of evolutionary genetics of speciation to systematizing, surveilling & controlling chromosome (genome) biology with mouse interspecific genomes x Y chromosomes inducing instability & Y chromosome wide alterations in epigenetic modifications of repetitive sequences, including, in the ~200 kb GATA/GACA-rich Sxr-regions (spanning Sry-loci) correlated with dysregulated mouse sex determination & differentiation as reporters.

(ii)                Eliciting biochemical, genetic, cellular & molecular mechanisms or factors regulating Recombination-Replication-Repair (RRR) systems in yeast including the HJ – STR complex, mammalian Oris & left handed zDNA sequences.

Systematization of the regulation of mammalian chromosome biology with evolutionary genetics & OMICs: A synopsis.

(Dissecting physiologically & developmentally relevant genetic regulation of mammalian chromosome biology with murine interspecific backcrosses, Y chromosomes, unstable direct and inverted repeat (DR & IR) sequences in ~200 kb Sxr-regions (spanning Sry loci), sex reversal phenotypes, mammalian Oris, HJ-STR complexes & zDNA structures.) 

These results led to the establishment of the conceptual foundations of the LSINJ. They constitute the very basis for switching paradigms from exclusive management of pathology(s) to including preemption of genetic diseases which is the core and legal mission of the LSINJ. These results and principles were presented in LSINJ Webinar 17 which is recorded and posted on the LSINJ website section on webinars: 

Switching from management of genetic lesions and their pathology(s) to preempting them – a sketch!

Of significance webinars 17 and 18 define the core mission, as well as the very process that led to the founding of the LSINJ. Webinar 18 is a webinar in which our work showed the instability of the mouse Y chromosome (including the Sxr-region, the sex determining Sry locus) in interspecific genomes. This finding was based on the known conceptual relationships of evolutionary genetics of speciation and genetic regulation of chromosome (and genome) biology scored with phenotypes of sex determination in the literature as well as in our data. We also analyzed related specific genetic, epigenetic, as well as mechanisms of DNA, recombination, replication and repair in model organisms

References:

(1) Shifting the therapeutic paradigm in medicine from post mutational (& pathological) intervention to preemption – a synopsis of the ‘nuts and bolts’ Ferez S. Nallaseth, MS, PhD, MOJ Proteomics Bioinform. 2019; 8(2):41‒43.

(2) Is There a Role for an Evolutionary Genetics Based Rational Health Policy In Global Biomedical, Health and Economic Policies? Nallaseth. J. Mol Biol OMIC

(3) What is the Life Sciences Institute of New Jersey? Why and how does it exist? What are its goals? Ferez S. Nallaseth, MS, PhD, Mol Biol OMIC 2015, 4: 3, (2168 - 9547 - 1000130.php?aid=60692)

Title Webinar 18: Systematization of the regulation of mammalian chromosome biology with evolutionary genetics & OMICs: A synopsis.

(Dissecting physiologically & developmentally relevant genetic regulation of mammalian chromosome biology with murine interspecific backcrosses, Y chromosomes, unstable direct & inverted repeat (DR & IR) sequences in ~200 kb Sxr-regions (spanning Sry loci), sex reversal phenotypes, mammalian Oris, HJ-STR complexes & zDNA structures.)

These results led to the establishment of the conceptual foundations of the LSINJ. They constitute the very basis for switching paradigms from exclusive management of pathology(s) to including preemption of genetic diseases which is the core and legal mission of the LSINJ. These results and principles were presented in LSINJ Webinar 17 which is recorded and posted on the LSINJ website section on webinars:

Title Webinar - 17: Switching from management of genetic lesions and their pathology(s) to preempting them – a sketch!

Of significance webinars 17 and 18 define the core mission, as well as the very process that led to the founding of the LSINJ. Webinar 18 is a webinar in which our work showed the instability of the mouse Y chromosome (including in the 200 kb Sxr-region spanning the sex determining Sry locus) in interspecific genomes. This finding was based on the known conceptual relationships of evolutionary genetics of speciation and genetic regulation of chromosome (and genome) biology scored with phenotypes of sex determination in the literature as well as in our data. We also analyzed related specific genetic, epigenetic, as well as mechanisms of DNA, recombination, replication and repair in model organisms.

In keeping with the history of these data we copy links to their presentations at various conferences or publications of results in various journals, below.

Dissecting physiologically & developmentally relevant genetic regulation of mammalian chromosome biology with murine interspecific backcrosses, Y chromosomes, unstable direct and inverted repeat (DR & IR) sequences in ~200 kb Sxr-regions (spanning Sry loci), sex reversal and differentiation phenotypes as markers:

(1) https://docs.google.com/viewer?a=v&pid=sites&srcid=ZGVmYXVsdGRvbWFpbnxuYWxsYXNldGhmc3xneDo3MzljZjI2ZWM3NGNlODAw

(2) https://docs.google.com/viewer?a=v&pid=sites&srcid=ZGVmYXVsdGRvbWFpbnxuYWxsYXNldGhmc3xneDo1YWJiNzQ3ZjhiMGJiMjU

(3) https://docs.google.com/viewer?a=v&pid=sites&srcid=ZGVmYXVsdGRvbWFpbnxuYWxsYXNldGhmc3xneDo2MGNlMDAzMTdjOWQxMjYz

(4) https://docs.google.com/viewer?a=v&pid=sites&srcid=ZGVmYXVsdGRvbWFpbnxuYWxsYXNldGhmc3xneDoyMjdjNGZkOWJiMTUwODNh

(5) https://docs.google.com/viewer?a=v&pid=sites&srcid=ZGVmYXVsdGRvbWFpbnxuYWxsYXNldGhmc3xneDo0YmI2YThlNzNlOTUxMGM3

(6) https://docs.google.com/viewer?a=v&pid=sites&srcid=ZGVmYXVsdGRvbWFpbnxuYWxsYXNldGhmc3xneDpjNDhiMzcyYmQ0MzUwNw

(7) https://docs.google.com/viewer?a=v&pid=sites&srcid=ZGVmYXVsdGRvbWFpbnxuYWxsYXNldGhmc3xneDpmODBmNTc2NjIxYWIxY2Y

(8) https://docs.google.com/viewer?a=v&pid=sites&srcid=ZGVmYXVsdGRvbWFpbnxuYWxsYXNldGhmc3xneDo2NmFjNjY2MGQ3ODk2NzY5

Chromosome and Genome Biology (DNA replication, recombination and repair), mammalian Oris, HJ-STR complexes & zDNA structures:

(1) https://docs.google.com/viewer?a=v&pid=sites&srcid=ZGVmYXVsdGRvbWFpbnxuYWxsYXNldGhmc3xneDoyY2ZiYTI2OGFmNDc0N2Q0

(2) https://docs.google.com/viewer?a=v&pid=sites&srcid=ZGVmYXVsdGRvbWFpbnxuYWxsYXNldGhmc3xneDo1MmU3YjgxMGFhY2Q1Zjg3

(3)https://docs.google.com/viewer?a=v&pid=sites&srcid=ZGVmYXVsdGRvbWFpbnxuYWxsYXNldGhmc3xneDoyMDY4ZDU4NTNlN2RiY2Nh

(4) https://pubmed.ncbi.nlm.nih.gov/8151772/

(5) https://docs.google.com/viewer?a=v&pid=sites&srcid=ZGVmYXVsdGRvbWFpbnxuYWxsYXNldGhmc3xneDpmMzFiODg5NDM3OGVjMzY

(6) https://docs.google.com/viewer?a=v&pid=sites&srcid=ZGVmYXVsdGRvbWFpbnxuYWxsYXNldGhmc3xneDo1OTRiMDI3Y2VmMjg4YzE3

(7) https://docs.google.com/viewer?a=v&pid=sites&srcid=ZGVmYXVsdGRvbWFpbnxuYWxsYXNldGhmc3xneDo2MThkZGViZjU1ZDFiNjk1

Report and recording:

(19A) Ralph Sherman, BA, 98th Birthday Commemoration by Prof. Lori McGrew, PhD , December 14th 2020

(II) LSINJ WEBINAR SERIES 2021 - 2022

(20) Prof. Lori McGrew, Ph.D. Webinar March 27th 2021

Title: Zebrafish as a model for anxiety

Position and Role in LSINJ:  Vice President for Executive Decisions

Interests: Neuropharmacology, anxiety disorders, depression, cannabinoids, herbal medicine, education, and public health

BioPic: https://www.lifesciencesinstitutenj.com/board-members#h.xui6jzx0y175

Abstract:

Zebrafish are an increasingly valuable model organism for pharmacologic and behavioral research. Zebrafish have well characterized behaviors that have been cataloged for use in assessment of spatial learning, anxiety, depression and other measures. In addition, pharmaceutical treatment of zebrafish can be accomplished by immersion, a low-stress drug delivery method. While significant homology exists between zebrafish and humans, some differences exist that may limit their utility as a model for serotonergic signaling. Specifically, the serotonin transporter and an important autoreceptor (5-HT1A) are duplicated in the zebrafish genome and the effect of this duplication on the serotonergic system is not entirely clear. The current studies are designed to add to the growing body of evidence concerning the behavioral effect of manipulating 5-HT and other biogenic amines. In order to accomplish this, zebrafish were treated with the SSRIs, citalopram and escitalopram, along with the triple reuptake inhibitor, 5-APB, and the monoamine releasing agent, BMPEA. The fish were then evaluated for changes in spatial learning, movement and anxiety by using a T-maze or novel dive tank. While there was no significant effect of SSRI treatment on spatial learning, there were significant decreases in movement and in body length for the SSRI treated groups.  There were also significant decreases in movement and apparent anxiety in the 5-APB and BMPEA treated groups.  These results are consistent with previous reports showing that increases in 5-HT that produce an anxiolytic effect both in zebrafish and in humans and support the value of continuing to cultivate this model. 

(21) Dr. Ferez S. Nallaseth, MS, PhD, Webinar 21, June 5th 2021

Title: Structural destabilization of Y chromosomes in interspecific backcrosses is consistent with variations in epigenetic modifications

Abstract: 

Title: Structural destabilization of Y chromosomes in interspecific backcrosses is consistent with variations in epigenetic modifications

Position and Role in LSINJ: Founding President, Chief Executive Officer (CEO), Chief Scientific Officer (CSO), Chief Financial Office (CFO) & Principal Donor;

Member of Working Group in LSINJ: (section in this website on Board Members)

External affiliations:  (section in this website on Board Members)

Position and Role in LSINJ: For more on Dr. Ferez S. Nallaseth, see the attachments and visit the LSINJ BM section on the site: https://www.lifesciencesinstitutenj.com/board-members, https://sites.google.com/site/nallasethfs/home/pdf-documents , https://www.researchgate.net/profile/Ferez_Nallaseth as well as his Profile on LinkedIn: https://www.linkedin.com/today/author/ferez-soli-nallaseth-m-s-ph-d-3112a714

Interests: Core Areas: Evolutionary Genetics of Speciation inducing dysfunctional regulation of Chromosome and Genome Biology; DNA recombination; DNA replication; Sex Determination; Speciation; Ancillary Areas: Neurophysiological and molecular basis of anoxia resistance in turtle brains; Structure/function and expression of Proteins from heterologous hosts; Multi-cue induction of skin morphogenesis in vitro; Overview in Life Sciences: Genetics (Somatic Cell, Mitochondrial, Yeast and Mouse (Epigenetics), Biochemistry and {Molecular, Stem/Cellular, Developmental, Cancer, Chromosome/Genome, Structural, Reproductive (Sex Determination and Gametogenesis) and Evolutionary (Speciation, Protein/Nucleotide Divergence)} Biology, Neurobiology, Virology and Microbiology (Microbial - Evolution, Ecology, Genetics).

Abstract

The Y chromosome (YPos) from Mus domesticus poschiavinus when backcrossed into the C57BL/6J inbred strain genome undergoes structural destabilization and functional inactivation; it is stable in the 129/Sv genome (Eicher et al, 1982; Nallaseth, 1992). Branched molecules migrate slower than linear double stranded molecules of equivalent molecular weight under agarose gel electrophoretic conditions (Bell & Byers, 1982). Characteristic electrophoretic mobility shifts of genomic copies of Y-linked repeated sequence restriction endonuclease fragments resulted from the formation of branched molecules since the native species was resistant to concentrations of Mung Bean Nuclease which digested the mobility shifted species to extinction. Variable numbers of genomic copies of YPos-linked repeated sequences of High Copy (HC or XYPos) female littermates migrated as the mobility shifted species. Sandwich Southern blots involving transfer through nitrocellulose to nylon membranes, identified Y-chromosomal sequences that were tightly/covalently bound to peptides; similarly to those previously identified in the genome (Neuer et al, 1983; Tse et al, 1980; Keeney et al, 1997). The pI and location of these peptides can be expected to affect the stability of the DNA duplex. Denaturation of restricted genomic DNAs from HC siblings under conditions of constant temperature of 560C but incremental pH, identified YPos fractions that displayed distinct melting profiles and mobility shifts. These results are consistent with variations in epigenetic modifications, including methylation patterns and qualitative and quantitative linkage of peptides to sequence elements on the YPos chromosome. Strain dependent variations in modifications could affect duplex stability and XY heteroduplex formation, which on resolution, lead to uncoupling of YPos chromosome linkage.

Our data and results in addition to ~100 years of results for the conceptual foundation of the core mission of the LSINJ:

Systematization of the regulation of mammalian chromosome biology with evolutionary genetics & OMICs: A synopsis.

(Dissecting physiologically & developmentally relevant genetic regulation of mammalian chromosome biology with murine interspecific backcrosses, Y chromosomes, unstable direct and inverted repeat (DR & IR) sequences in ~200 kb Sxr-regions (spanning Sry loci), sex reversal phenotypes, mammalian Oris, HJ-STR complexes & zDNA structures.)

Position and Role in LSINJ: Founding President, Chief Executive Officer (CEO), Chief Scientific Officer (CSO), Chief Financial Office (CFO) & Principal Donor; Group Leader – Group on Sex Determination and Gametogenesis; Reproductive Biology; Evolutionary Genetics, Speciation, Chromosome (Genome Biology); Focus on mouse Y chromosome biology; Co-Group Leader of Group on Developmental Biology and Reproductive Biology; Member of multiple groups projecting ancillary missions of the LSINJ.

Interests: Life Sciences: Core Areas: Evolutionary Genetics of Speciation inducing dysfunctional regulation of Chromosome and Genome Biology; DNA recombination; DNA replication; Sex Determination; Speciation; Ancillary Areas: Neurophysiological and molecular basis of anoxia resistance in turtle brains; Structure/function and expression of Proteins from heterologous hosts; Multi-cue induction of skin morphogenesis in vitro; Overview in Life Sciences: Genetics (Somatic Cell, Mitochondrial, Yeast and Mouse (Epigenetics), Biochemistry and {Molecular, Stem/Cellular, Developmental, Cancer, Chromosome/Genome, Structural, Reproductive (Sex Determination and Gametogenesis) and Evolutionary (Speciation, Protein/Nucleotide Divergence)} Biology, Neurobiology, Virology and Microbiology (Microbial - Evolution, Ecology, Genetics).

BioPic: https://www.lifesciencesinstitutenj.com/board-members#h.p_Q1kjpjYAYSNM 

(22) CEO/VP Mirhasan H. Hasanli, B.S.C.S.E., Webinar July 3rd 2021

Title: DEB Epidermolysis Bullosa and mRNA miRNA methodology 

Position and Role in LSINJ: Vice President of Computer Science, Programming, Artificial Inelligence, Machine Learning, Visual Imaging, Geographical Information Systems, Satellite Technology 

Member of Working Group in LSINJ: (section in this website on Board Members)

External affiliations:  (section in this website on Board Members)

Core Interests:  Computer Science, Programming, Artificial Inelligence, Machine Learning, Visual Imaging, Geographical Information Systems, Satellite Technology 

BioPic: LSINJ BM section on the site: https://www.lifesciencesinstitutenj.com/board members#h.rwqx47628vnm as well as his Profile on LinkedIn: https://www.linkedin.com/in/mirhasanhajihasanli/

Abstract:

Epidermolysis Bullosa is a rare and inherited disease that manifests itself with the formation of bullae depending on its types in the body or organs. Extracellular vesicles are nanoparticles of various types secreted in every cell. EVs can be used for purposes such as suppression, wound healing, and cancer treatment. EVs, whose natural function is carrier, can be used for research, development, etc. It is very useful to use it for situations. Transport of drugs and bioactive compounds is done by exosomes. Studies on this have produced promising results.

Our aim is to administer miRNAs that degrade the damaged mRNA in the patient, and healthy mRNAs to replace the cleaved mRNAs via extracellular vesicles. It is aimed to make localized and controlled drug administration by using microneedle petch or an equivalent product that can be used like it.

It is planned to carry out the necessary scientific work in the field of recognizing the disease and accepting it as a part of the society by carrying out studies in the field of social awareness.

(23) CEO/Director Mohammed (Mo) Abouelsoud, Webinar August 28th 2021

Webinar Title:   'U and Noninvasive Neuromodulation'

Position and Role in LSINJ:  Director – Noninvasive Deep Brain Stimulation in Trauma Resolution & Stress Management; Director of Outreach for Urban Centers in the USA and Egypt, Africa; Member Groups on Biophysics, Electronics and Technology Transfer Operations; Member Group on Neurosciences, Neuropathology, Neuropsychiatric Diseases, Experimental Psychology, Anoxia Tolerance, Thermodynamic States of Hypoxic Neurophysiological Systems.

BioPic: https://www.lifesciencesinstitutenj.com/board-members#h.ydfkk9htwdgf 

Abstract:

U: The Mind Company is led by Mohammed (Mo) Abouelsoud. They create Portable Noninvasive Neuromodulation devices for a wide variety of neuropsychiatric disorders. They are also heavily interested in Neuromodulation research and the future of neuroscience and man!!

Message from Mo: he is going to give welcomes to everyone, share information about U, and talk about on-going research projects in the field of neuroscience and technology.

(24) Dr. Ferez S. Nallaseth, MS, PhD, Webinar 24, October 30th,  2021(Originally scheduled for October 9th 2021 but due to cyberattacks rescheduled) 

Title: 

Species incompatibility induced dysregulation of Y chromosome and genome biology: identification of potential mechanisms with assays for viral, yeast, mouse bovine and human systems in selections of component mechanisms (DNA replication, recombination, repair, modification and structure, chromatin remodelling factors and neocentromeres)

Abstract: 

Classical Evolutionary Genetics of Species Incompatibility inducing dysregulation of Y chromosome and genome biology is a powerful approach for systematizing (evolutionarily, physiologically, biochemically and developmentally) relevant mechanisms and genetic networks regulating the maintenance of the mammalian genome. Dysregulation of these networks results in the insertion of genetic disease lesions into the genome. The inductive agents and processes have multifactorial origins. We define all factors, complexes and events either preceding or causing the insertion of the lesion by the term Mutome. In combination with high resolution contemporary methods classical methods can be applied to assembling systems for the surveillance and control of these networks in real times permitting the preemption of genetic disease lesions. We refer to this system as the Combinatorial Approach in Real Time Operations (CA RTO).

After detection by ‘panning’ of Species Incompatibility induced genetic lesions, it is necessary to identify the responsible genetic, molecular and biochemical mechanisms. Our work has led to potential applications of assays. These include viral, yeast, mouse and bovine organisms in selections of systems for DNA replication, recombination, repair, modification and structure in defining CA RTO of Mutomes. The work involves or applies to genetics, biochemical, and molecular, cellular, developmental and evolutionary dimensions of the dysregulation of Y chromosome biology​and sex determination induced by Species Incompatibility. Varying extents and progressions of our work on regulation of 6 areas of Chromosome/Genome Biology will be presented. They will range from results in studies on (i) viral and cellular Origins of DNA replication, (ii) meiotic and mitotic DNA recombination in yeast (S. pombe M26 hotspot and S. cerevisiae Holliday Junction (HJ)-STR complex formation), (iii) Specific sites of Demethylation of bovine CYP17 (steroid 17 alpha-hydroxylase) in bovine cells explanted into culture from the bovine Adrenal Cortex, (iv) epigenetic modifications of mouse Y sequences, (v) zDNA structure in the 'Comparison of Inbred Strains and Wild Mice Recombinases’ ,(vi) interactions of HRX (human trithorax) chromatin leukemogenic factor with replication and chromatin remodeling proteins (SET, TAF, & NAP) and (vii) application of FISH for mapping structure function relationships of human neo centromeres and chromosome breakages

The above composite of scientific concepts, assays and results of our work are based ​​on literature spanning 150 years and hundreds of millions of results on the Induction of dysregulated Chromosome/Genome Biology. In addition the role played by Species Incompatibility and scored by Phenotypes such as Sterility, Inviability and Sex Reversal are extensively investigated. ​Some of this work, has contributed to the founding principles of the LSINJ (step 4 of the ​​​​series presented).

The scientific, societal and historical nature and dimensions of this work are published (Nallaseth et al, 2021, link below)

​https://actascientific.com/ASMI/pdf/ASMI-04-0918.pdf ​

Title:

'Species incompatibility induced dysregulation of Y chromosome and genome biology: identification of potential mechanisms with assays for viral, yeast, mouse bovine and human systems in selections of component mechanisms (DNA replication, recombination, repair, modification and structure and chromatin remodelling factors).'

​Abstract:​

Classical Evolutionary Genetics of Species Incompatibility inducing dysregulation of Y chromosome and genome biology is a powerful approach for systematizing (evolutionarily, physiologically, biochemically and developmentally) relevant mechanisms and genetic networks regulating the maintenance of the mammalian genome. Dysregulation of these networks results in the insertion of genetic disease lesions into the genome. The inductive agents and processes have multifactorial origins. We define all factors, complexes and events either preceding or causing the insertion of the lesion by the term Mutome. In combination with high resolution contemporary methods classical methods can be applied to assembling systems for the surveillance and control of these networks in real times permitting the preemption of genetic disease lesions. We refer to this system as the Combinatorial Approach in Real Time Operations (CA RTO).

After detection by ‘panning’ of Species Incompatibility induced genetic lesions, it is necessary to identify the responsible genetic, molecular and biochemical mechanisms. Our work has led to potential applications of assays. These include viral, yeast, mouse and bovine organisms in selections of systems for DNA replication, recombination, repair, modification and structure in defining CA RTO of Mutomes. The work involves or applies to genetics, biochemical, and molecular, cellular, developmental and evolutionary dimensions of the dysregulation of Y chromosome biology​and sex determination induced by Species Incompatibility. Varying extents and progressions of our work on regulation of 6 areas of Chromosome/Genome Biology will be presented. They will range from results in studies on (i) viral and cellular Origins of DNA replication, (ii) meiotic and mitotic DNA recombination in yeast (S. pombe M26 hotspot and S. cerevisiae Holliday Junction (HJ)-STR complex formation), (iii) Specific sites of Demethylation of bovine CYP17 (steroid 17 alpha-hydroxylase) in bovine cells explanted into culture from the bovine Adrenal Cortex, (iv) epigenetic modifications of Y sequences, (v) zDNA structure in the 'Comparison of Inbred Strains and Wild Mice Recombinases’ ,(vi) interactions of HRX (human trithorax) chromatin leukemogenic factor with replication and chromatin remodeling proteins (SET, TAF, & NAP).

 The above comosite of scientific concepts, assays and results of our work are based ​​on literature spanning 150 years and hundreds of millions of results on the Induction of dysregulated Chromosome/Genome Biology. In addition the role played by Species Incompatibility and scored by Phenotypes such as Sterility, Inviability and Sex Reversal are extensively investigated. ​Some of this work, has contributed to the founding principles of the LSINJ (step 4 of the ​​​​series presented).

The scientific, societal and historical nature and dimensions of this work are published (Nallaseth et al, 2021, link below)

​https://actascientific.com/ASMI/pdf/ASMI-04-0918.pdf ​

(25) Vice President/CEO Elizabeth Parrish, MBA, Webinar 25, December 11th 2021

Position and Role in LSINJ: VP for Biotech, Corporate & Civic Outreach & Public Relations

Interests: Aging, Cellular & Genetic Degeneration; Telomeres; RNA technology

Affiliations: Chief Marketing Officer and Media Officer at RNAx Ltd.; Founder and CEO of BioViva, LLC; Founder of BioTrove Investments LLC and the BioTrove Podcasts, found at iTunes; Founding Member of International Longevity Alliance (ILA); Founding Member of the American Longevity Alliance (ALA)CCO, CMaO, CPSE – USA of LSINJ; Buckinghamshire New University and Magna Carte College in Oxford, awarded Strategic Management and Leadership Diploma (combined for award of International MBA, 2018 - 2021);  University of Washington, Seattle (BS, in progress); Seattle Central Community, WA, awarded Associates of Science with Honors; 

(26) Vice President/Collin C. White, B.S., Webinar 26, February 26th 2022 

Position and Role in LSINJ: Vice President for LSINJ collaborations in Imaging, Research & Development in Cytometry and Analytical Biochemistry as they apply to the fields of Toxicology, Pharmacology, Immunology or Cancer Research; Vice Lab Manager & Research Facility Supervisor

Interests:  Cytometry and Analytical Biochemistry in the fields of Toxicology, Pharmacology, Immunology or Cancer Research; Mouse Models, Spheroids and 3D cultures; Laboratory Technology and Instrumentation

Title of webinar: Toxicological characterization of an immortalized glutathione-deficient hepatic cell line in traditional monolayer culture vs 3D spheroids in microphysiological chambers (Co-authors: Collin C. White, Nikki Nguyen, Dianne Botta and Terrance J. Kavanagh; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195 (USA)

Abstract of webinar:

The antioxidant glutathione (GSH) is important in scavenging electrophiles, reducing reactive oxygen species, and as a substrate for glutathione S-transferase (GST)-mediated detoxification. Glutamate cysteine ligase (GCL; the rate-limiting enzyme for GSH synthesis) is composed of catalytic (GCLC) and modifier (GCLM) subunits. Our lab developed GCLM null (Gclm -/-) mice by replacing the first exon with a b-galactosidase (b-gal)/neomycin phosphotransferase fusion gene. Gclm-/- mice have compromised GSH synthesis with 10 – 20 % of normal GSH levels. They also express b-gal activity proportional to the transcriptional activity of the Gclm promoter, which is a known target of the oxidative stress-responsive transcription factor NRF2. Immortomouse® (IM; Charles River), a transgenic mouse with a SV40 large T-antigen fused to H-2Kb (MHC Class 1 antigen), can be used to produce immortalized primary cell lines. We bred IM mice to Gclm -/- and Gclm +/+ mice to establish immortalized hepatocyte cell lines from IM/Gclm -/- and IM/Gclm +/+ mice (IM/KO and IM/WT cells, respectively). As expected, IM/KO cells have 8% of the GSH levels of IM/WT cells. Moreover, in 2D monolayer culture IM/KO cells are sensitive, and IM/WT cells are resistant to hydroquinone (HQ)-induced cytotoxicity. We treated IM/KO and IM/WT cells cultured as 2D monolayers or 3D spheroids with increasing concentrations of hydroquinone (HQ) for 24-hr, and then stained with the b-gal substrate DDAOG. The fluorescent product DDAO was then quantified by laser scanning cytometry as a measure of Nrf2-dependent Gclm promoter activity. HQ treatment resulted in a dose-dependent increase in DDAO fluorescence in both 2D monolayer cultures and 3D spheroids in microphysiological chambers. IM/KO 2D monolayer cultures were more responsive to HQ treatment than the 3D IM/KO spheroids. Since these immortalized IM/KO hepatocytes and Gclm-/- mice are known to exhibit GSH-dependent alterations in chemical sensitivity and oxidative stress, they can serve as a convenient system for in vitro to in vivo extrapolation in mechanistic toxicology studies.

Report:

We would like to thank VP Collin White for overcoming several app challenges and presenting an excellent webinar. It covered cutting edge subjects and a multitude of applications. Including the analyses of multiple enzymes eg for Glutathione synthesis, and tissues, etc. Methods included Microfluidic Chips for quantitative and highly regulated delivery of media, reagents, stimulants, substrates and nutrients and with simultaneous withdrawal of products and metabolic wastes. Other approaches were more established and included optics, fluorescence markers (GFP), monolayer (1D) or bilayer (2D) and spheroid 3D cultures, kinetics, metabolics, mouse models and a multitude of other systems.  

I had worked on and presented a similar system, namely Hanging Drop (HD) 3D cultures (LSINJ webinar 15). Collin and I had a meaningful conversation with prospects for a possible collaboration. 

On downloading today's webinar we found although Speakers were visible there was no audiovisual recording. VP David Adebayo informed us that he could hear Collin and I speak but could not see the slides. We have sent a message to the Support desk for Skype. They have resolved similar issues in the past and hopefully will do so with this issue. We will send out a complete report.

Report, recording and pdf:

(28) Vice President/Prof. Hafiz S. A. Yahya, Ph.D. , Webinar 28, April 9th, 2022 

(29) Vice President/Dr. Sandeep K. Singh, Ph.D. , Webinar 29, June 18th, 2022 

Title: Therapeutic potential of synthetic as well as herbal compounds against Alzheimer's disease using Drosophila model system 

Abstract: Alzheimer’s disease (AD) is a neurodegenerative disease that involves the aggregation and deposition of the mainly two polypeptides β-amyloid (Aβ42) and Tau. The former is the result of processing of APP by β and γ-secretases while later one form neurofibrillary tangles (NFTs) which consist of paired helical filaments of hyper phosphorylated tau protein. To date, it remains unclear about the etiology of the disease and no cure is available. Therefore people are continuously working to find out a suitable therapeutic target for the treatment of AD. In the current scenario, major focus involves deciphering the role of numerous synthetic as well as herbal compounds as inhibitors of Aβ aggregation. Here in this webinar I will be discussing about the neuroprotective role of synthetic as well as herbal compounds against Aβ42 toxicity in Drosophila model of Alzheimer’s Disease (AD) which involving use of some synthetic (Copper Chelator and flavonoid derivatives) as well herbal compound (Aloe vera) as a potential neuroprotective agent against Aβ mediated neurotoxicity in amyloidosis in Drosophila in vivo.

Position and Role in LSINJ: Vice President for Neurotherapeutics, Neurotoxicity Research, Oxidative Medicine and Cellular Longevity; Co-Group Leader – Group of Neurosciences, Neuropathology Diseases, Anoxia Tolerance, Thermodynamic States of Hypoxic Neurophysiological Systems; Co-Group Leader on Educational Outreach of the LSINJ on the Asian sub-continent; Co-Group Leader on Pharmaceutical Outreach of the LSINJ in India

Interests: Neuroscience and Molecular Biology

Member of Working Group in LSINJ and Group Leader: Group Leader of Group on Neurotherapeutics, Neurotoxicity Research, Oxidative Medicine and Cellular Longevity Neurosciences, Neuropathology; Co-Group Leader on Group of Anoxia Tolerance, Hypoxic Neurophysiological Systems; Co-Group Leader on Educational Outreach of the LSINJ in India; Co-Group Leader on Medical Outreach of the LSINJ in India; Co-Group Leader on Pharmaceutical Outreach of the LSINJ

Affiliation(s):  Founder President, Indian Scientific Education and Technology (ISET) Foundation, Indian Scientific Education and Technology Foundation, 594 Kha/123, Sahinoor Colony, Nilmatha, Cantt, Lucknow - 226002, India

Biopic: https://www.lifesciencesinstitutenj.com/board-members#h.v9f1t1rfxxg 

(31) Senior Vice President/Depart. Head/Prof. , Syed M. Ahmed, Ph.D. , Webinar 31, October 14th, 2023 

Title: Sustainable Construction: Challenges & Opportunities

Abstract: 

Sustainable construction refers to a structure, the construction process and occupancy processes that are environmentally responsible and resource efficient throughout a building’s life-cycle from location to design, construction operation, maintenance, renovation, and demolition. Sustainable construction is generally used to describe the application of sustainable development to the construction industry. Sustainability leads to a better quality of life; not only for those in the sustainable site, but for all of us. We will discuss the triple bottom line and the themes of environmental, social, and economic accountability; and the life cycle of a building and the construction process. Multiple areas of sustainability have been considered, including green home building, the commercial industry, sustainable materials, and their overlapping parts. Included are quick statistics and charts showing data from the leading members of sustainability, USGBC (United States Green Building Council) and LEED (Leadership in Energy and Environmental Design). Also included are the world’s leaders in sustainability, the nations’ leaders, and some of their most notable projects.

Report and Recording:

Report: 31st LSINJ Webinar by Prof. Syed M. Ahmed, PhD: Sustainable Construction: Challenges & Opportunity

Webinar Date: Saturday, 10.30 am, October 14th 2023 (US EST)

31st LSINJ Webinar Title: 'Sustainable Construction: Challenges & Opportunities'  

Position and role in LSINJ: Senior Vice President (SVP) and Chief Engineering Officer (CEnO); Oversees all Engineering Projects of LSINJ

Affiliation(s): External: Professor & Department Head, Syed M. Ahmed, PhD, Department of Building Construction   Science in the College of Architecture, Art & Design at Mississippi State University (2023 - present)

Interests: see profile below 

Profile on the LSINJ website: https://www.lifesciencesinstitutenj.com/board-members#h.v9f1t1rfxxg 

Good day Board Members,

Last Saturday Prof. Syed M. Ahmed delivered the 31st LSINJ Webinar, and with it the 2023 – 2024 LSINJ Webinar season. It was well received first by 5 attending BM, and then by another 5 BM who were unable to attend as a post webinar recording on Skype.

The webinar presented an in-depth report on all the stages of construction. Including those with incremental or significant contributions detrimental or even toxic effluent discharges into environmental and ecosystems. Options by globally placed nations to decreasing these releases were innovative and discussed.  Surprises such as heavy environmental costs of Mortar and Brick side products necessitating their replacement in new Kilns and materials emerged. Innovations such as the use of plastics in constructing roads in India were a surprise.

The fundamental resistance to Green Energy and Construction was also addressed. Dr. Ahmed showed that upfront costs were high and returns on investment were low eventually they contributed significantly greater savings over traditional Carbon release intensive construction.

Dr. Ahmed emphasized that the gradually emerging circular recycling materials approach is supplementing and replacing the historical linear, use and discard materials approach global/international industrial and domestic enterprises. The reason for this decision are economic as well as environmental considerations bringing a sea change in manufacturing, construction and industrial plans and projections. So much so that Professor Syed Ahmed quoted a rigid traditional company as having reinvented itself as well as its title from British Petroleum to Beyond Petroleum – with research and innovation to match.

(32) Senior Vice President/Dean AMU LSINJ/Prof. , Hafiz Shaeque Yahya, Ph.D. , Webinar 32, December 2nd, 2023 

Title: Conservation of Biodiversity at the Periyar Tiger Reserve of India

Abstract: The Periyar Tiger Reserve (PTR) is one of the most beautiful protected areas in India. It is situated amidst picturesque and scenic terrains of the Western Ghats in Kerala state. I had the opportunity to conduct research over the extended period from 1977 to 1980 on the Comparative Ecology and Biology of Barbets. This was for partial satisfaction for my Doctorate (Ph.D.) degree under the supervision of Dr. Salim Ali. Encompassing over 900 sq km the biodiversity of PTR is quite rich comprising over 500 plant species; 300 species of birds; 75 species of mammals; and with abundance of lower fauna.
Initially protected as Nilikam Patty Wildlife Sanctuary by Maharaja of Travencore. After India's independence it was first designated as the Periyar Wildlife Sanctuary in 1958, then as the 9th Tiger Reserve in 1978 and finally as the National Park in 1998. The PTR is also designated as an Elephant Reserve. Given its high ecological value and environmental magnificence PTR draws tourist and scientist alike, representing a highly significant number of visitors from India and abroad.

Two species of barbets are endemic to Western Ghats and they occur in the PTR. In this presentation besides describing their ecology and general habits, I will also highlight salient features of their feeding and breeding biology including food items, feeding cycle, food preference, feeding competition, pair formation, nest site selection, nest excavation, egg laying, incubation period, percentage of attentiveness during incubation, nest feeding, nest cleaning and overall breeding success.

I will also discuss how these two sympatric and congeneric species are able to survive successfully. Doing so in the same habitat by adopting the mechanism of ecological isolation. An essential lesson that humankind often fails to appreciate, with the consequence of several global conflicts and wars.

Report:

Good day Board Members,

The 32nd LSINJ Webinar was presented last Saturday December 2nd 2023 by SVP/Dean/Professor (Emeritus) Hafiz S. Yahya, PhD.

It was entitled: 'Conservation of Biodiversity at the Periyar Tiger Reserve of India.' 

Several Board Members from 3 continents were in attendance for at least some period of the ~ 2-hour long webinar. The recording is available via this link:

https://www.lifesciencesinstitutenj.com/webinars-by-board-members-from-global-sites#h.ktia6trdl5zg

The BioPic for Prof. Yaha:

https://www.lifesciencesinstitutenj.com/board-members#h.p_De_e42NRhESe

Professor Yahya received his Doctorate in Ornithology specializing in Indian Barbets. However, as is inevitable, he has become committed to conservation, the environment ecological diversity and evolution. He has worked extensively working with birds, habitats, flora and fauna on 4 continents while specializing on the Indian subcontinent.

His passion and expertise as a Naturalist, were clearly articulated with the many technical and scientific details that he shared about his personal experiences in the Periyar Tiger Reserve, with Barbets, the Envronment and History associated with conservation on the subcontinent.

In his own words: ‘Two species of barbets are endemic to Western Ghats and they occur in the PTR. In this presentation besides describing their ecology and general habits, I will also highlight salient features of their feeding and breeding biology including food items, feeding cycle, food preference, feeding competition, pair formation, nest site selection, nest excavation, egg laying, incubation period, percentage of attentiveness during incubation, nest feeding, nest cleaning and overall breeding success. I will also discuss how these two sympatric and congeneric species are able to survive successfully. Doing so in the same habitat by adopting the mechanism of ecological isolation. An essential lesson that humankind often fails to appreciate, with the consequence of several global conflicts and wars.’

It was generally accepted that Prof. Hafiz Shaeque Yahya had given us an exceptional overview of all these dimensions of conservation, the challenges faced by it with special reference to the ‘Periyar Tiger Reserve of India’ and Barbets of India. 

Board Members who could not attend will have access to recordings of Webinars and Administrative meetings on Skype (for a month) and the LSINJ website permanently. 

(33) Senior VP/Prof./Director Dickson Achimugu Musa, PhD, 33rd LSINJ Webinar, Saturday January 27th,  2024

Title: Leveraging Nigeria's Rich Biodiversity for Imnproved Health and Sustainable Development

Abstract: Nigeria's diverse flora and fauna, particularly its indigenous medicinal plants, have long been utilized in traditional medicine. However, these resources have been understudied and underutilized. The growing global demand for plant-based medicines, coupled with Nigeria's large population of researchers, presents a unique opportunity to explore the potential of these resources. Nigeria's biodiversity, including medicinal plants, microorganisms, marine organisms, and animals, offers the potential for drug discovery. To ensure the safety and quality of plant-based medicines, standardization of production and handling methods is necessary, which can be achieved through pharmacological biochemistry research. This study aims to highlight the therapeutic potential of Nigeria's rich biodiversity and advocates for their integration into pharmaceutical development, with the goal of improving health outcomes and stimulating economic growth. Although the pharmaceutical industry had moved away from pursuing natural products in the 1990s due to the technical challenges associated with drug discovery, recent advances in technology and science have reopened the field, leading to renewed interest in natural products, particularly in the fight against antimicrobial resistance. This research has focused on various aspects of Nigerian biodiversity, including the isolation and characterization of natural products, pharmacological screening for drug discovery, and the mechanism of action of natural products. The study has also explored the use of in silico approaches to address issues in drug discovery and has developed a process for using underutilized starches as alternatives to conventional pharmaceutical excipients. However, the study also highlights the threats posed to the conservation of indigenous medicinal plants in Nigeria by population growth, anthropogenic activities, and climate change. The study advocates for sustainable practices that prioritize biodiversity conservation and promote resilience in the face of environmental challenges. Additionally, the study explored the underlying mechanisms of antimicrobial resistance in typhoid fever and discovered GM fingerprints in Nigerian foods. The impact of clinical biochemistry and epidemiology on modern medicine was also explored. The study also looked at the mycotoxin risks and health hazards associated with tobacco consumption. In conclusion, this research positions Nigerian biodiversity as a vital component for global health advancement and sustainable development. The study emphasizes the importance of collaborative efforts, infrastructure development, and government support in harnessing the full potential of biodiversity. The study also highlights the need to prioritize the conservation of indigenous flora and fauna, integrate traditional knowledge, and foster resilience. The study provides valuable insights for policymakers and stakeholders in leveraging Nigeria's rich biodiversity for a sustainable and health-conscious future.

Proceedings: Proc.:33rd LSINJ Webinar, 1.27.2024: SVP/Prof. Dickson A. Musa: 'Leveraging Nigeria's Rich Biodiversity for Improved Health and Sustainable Development'

Good day Board Members, 

This webinar message is supplemented with previous List of titles and presenters of previous LSINJ Webinars. 

Best regards,

Ferez

Ferez S. Nallaseth, MS, PhD

Good day Board Members,

SVP/Professor Dickson Achimugu Musa, PhD will present the rescheduled 33rd LSINJ Webinar  at 7.30 am (US PST) on Saturday, January 27th 2024. As some BM are in time zones that make this an unreasonable time, requests to shift the start time will be circulated. However recordings of the webinar will be circulated as before.

Webinar Title: Leveraging Nigeria's Rich Biodiversity for Improved Health and Sustainable Development 

Speaker Titles: 'Director: Trans-Saharan Disease Research Centre, IBB University, Lapai, Nigeria

Senior Vice President (Genetic Diversity & Microbial Ecosystems): Life Sciences Institute of New Jersey, Belle Mead NJ, USA'  

External Affiliations and Profile on the LSINJ website:  Director of Trans - Saharan Disease Research Center, IBB University, Lapai, Nigeria; Deputy Dean, Faculty of Natural Sciences , Ibrahim Badamasi Babangida (IBB) University, Lapai, Nigeria; Professor and Head, Department of Biochemistry, Faculty of Natural Sciences IBB University, 911101, Lapai, Niger State, Nigeria; Public Relations Officer, Nigerian Society of Biochemistry and Molecular Biology; Chairman, North Central Zone, Biotechnology Society of Nigeria

Link to Full Profile on the LSINJ website: https://www.lifesciencesinstitutenj.com/board-members#h.p_z84hVpgP5g6k

Board Members who cannot attend will have access to recordings of Webinars and Administrative meetings on Skype (for a month) and permanently the LSINJ website. We will contact Google W.S. to restore recording videos on both PC and Mac platforms.

Titles of current and previous LSINJ Webinars by BM in the series 2019 - 2024:

https://www.lifesciencesinstitutenj.com/webinars-by-board-members-from-global-sites 

(33) This is the 33rd webinar to be presented by SVP/Prof. Dickson Achimugu Musa, PhD everaging Nigeria's Rich Biodiversity for Improved Health and Sustainable Development 

The other diverse Biocentric webinars in the eclectic LSINJ webinar series are listed. In order, the webinars were:

(1) the first by, Prof. George Perry, on ' In search of a therapy for Alzheimer’s disease', (2) the second by, Dr. Ferez S. Nallaseth on 'Switching from management of genetic lesions and their pathology(s) to preempting them – a sketch! on Y chromosome biology - Evolutionary Genetics of Speciation, Sex Determination, and the LSINJ mission' (3) the fourth by, Prof. Kholis Audah, on harvesting Indonesian Biodiversity for therapeutic interventions, (4) the 5th by, Dr. Adam Bogart, on 'Neuro-imaging in Psychopharmacology, 1896 - 2005', (5) the sixth by, CEO Liz Parrish, on 'Creating Human Health Span and Longevity Through Gene Therapy', (6) the seventh by, Prof. Hafiz Yahya, on 'Conservation of Avian diversity in India' and (7) the eighth webinar by Dr. Alex Diaz, on 'Merging Interoceptive Knowledge with Peak Performance in Sports', (8) the ninth webinar by, Prof. Nirmali Wijegoonawardana, on 'Medicinal plants in Sri Lanka: A review' , (9) the tenth webinar by, VP Ralph Sherman, on 'Transition State Theory (TST) - Case: Sodium (Na+) transport in Alzheimer's Disease.', (12) the twelfth webinar by, BM Sina Varmaghani, MS, on 'A pathological review on spatial memory', (13) the thirteenth webinar, by VP/Deputy Dean, Dickson Achimugu Musa, on 'Drug Discovery From Nigerian Biodiversity: Challenges and Prospects' , (14) the fourteenth webinar by VP Jean Plante which was a repetition version of the 11th webinar as VP/Consultant Jean Plante felt that the subject matter had not been adequately discussed. It was a presentation in which a combination of Philosophy, Medical, Biophysical, Bioengineering and Physicochemical sciences were delivered, as reflected in the title of the webinar - ‘REALITY and, our reality', (15) the fifteenth webinar given by me (Dr. Ferez S. Nallaseth, MS, PhD) on ' Morphogenesis of skin in 3D co-cultures - sorting and mixing of interspecific, intra-specific, differentiated and stem cells traced with lineage specific keratins,(16) the 16th webinar, by me (Dr. Ferez S. Nallaseth) on ' Comparative evolutionary analysis of the neurophysiological and molecular basis of anoxia resistant turtle and hypoxia sensitive mammalian brains to identify oxygen responsive targets in neurodevelopment.' (17) the 17th webinar, by me (Dr. Ferez S. Nallaseth) on Switching from management of genetic lesions and their pathology(s) to preempting them – a sketch! (18) the 18th Webinar, by me (Dr. Ferez S. Nallaseth) on Systematization of the regulation of mammalian chromosome biology with evolutionary genetics & OMICs: A synopsis. , (19) the 19th webinar was presented in two parts - Webinar (19A) by Prof. Lori McGrew and the Sherman Family presented 'a commemoration of the 98th Birthday of VP Ralph Sherman with a presentation of his lifetime of contributions' and Webinar (19B) by Director Percy Ichchaporia (MSc, MBioTech) on 'Three undertakings: Open Innovation, Immunoassays and the biological characterization of cell wall degrading enzyme(s) in plants' ,(20)  the 20th webinar was presented by Prof. Lori McGrew on ‘Zebrafish as a model for anxiety', (21) the 21st webinar was presented by Fnd Pres./CEO,CSO, CFO, Dr. Ferez S. Nallaseth on 'Structural destabilization of Y chromosomes in interspecific backcrosses is consistent with variations in epigenetic modifications ', (22) the 22nd webinar was presented by CEO/VP Mirhasan H. Hasanli DEB Epidermolysis Bullosa and mRNA miRNA methodology, (23) the 23rd webinar was presented by VP Mohammed Abouelsoud 'U and Noninvasive Neuromodulation', (24) the 21st webinar was presented by Fnd Pres./CEO,CSO, CFO, Dr. Ferez S. Nallaseth on  'Species incompatibility induced dysregulation of Y chromosome and genome biology: identification of potential mechanisms with assays for viral, yeast, mouse bovine and human systems in selections of component mechanisms (DNA replication, recombination, repair, modification and structure, chromatin remodelling factors and neocentromeres) ', (25) the 25th webinar was presented by Vice President/CEO Elizabeth Parrish, MBA on 'BioViva where are you going.' (26) the 26th webinar was presented by Vice President / Colin C. White, BS 'Toxicological characterization of an immortalized glutathione-deficient hepatic cell line in traditional monolayer culture vs 3D spheroids in microphysiological chambers', (27) the 27th webinar was presented by Vice President/Member Rene' J.P. Musters, PhD on  'Nanoscopic Imaging of The Cell Nucleus and The 3D Genome: One Dot At A Time', (28) the 28th webinar was presented by Vice President/Dean Hafiz S.A. Yahya, PhD on ' An Overview of the status and conservation of Hornbills with particular reference to Narcondam Hornbill, Acerus nacondami occurring at Narocondam island', (29) the 29th webinar entitled 'Therapeutic potential of synthetic as well as herbal compounds against Alzheimer's disease using Drosophila model system', (30) the 30th webinar/meeting was an impromptu delivery by Dr. Ferez S. Nallaseth in lieu of  postponed webinar, (31) the 31st webinar was presented  by VP/Prof. Syed M. Ahmed, PhD entitled 'Sustainable Construction: Challenges & Opportunities' , (32)  the 32nd webinar was presented by SVP/Dean (Emeritus) Hafiz Shaeque Yahya, PhD entitled ' Conservation of Biodiversity at the Periyar Tiger Reserve of India.' 

A non-Biocentric webinar:

(3) the third webinar was a non-Biocentric webinar by, Prof. & Chair Syed M. Ahmed, on Construction Management and Engineering - its History, Challenges and Prospects in a Green World. All the webinars elicited interest and interactions,

How to join the Webinar on the Skype LSINJ - WEBINAR Group I:

(AVOID LSINJ - WEBINAR Group II)

The Skype problem with different people joining the LSINJ Skype call seems to have been solved by one (1) person either joining or calling the whole call group that Prof. Nirmali Wijegoonawardana has assembled. Subsequently all BM need to join this group call rather than individually logging in. The group is now renamed:

Skype: LSINJ - Webinar Group I

We will be available to assist with the call from 7.00 am (PST US) onwards. To avoid disturbance of inactive BM, through this call their Skype addresses have been removed. Also background TV and other activities make the Skype call reception difficult for all BM - so kindly mute or turn them down.

How to join the Skype call?

(i) Skype procedures require first logging into the Skype app. Your Skype Contact list should already have the LSINJ - Webinar Group I that has been set up by Prof. Nirmali Wijegoonawardana,

(ii) If a member of the LSINJ - Webinar Group I is active you will find the words in a green cylindrical tab with the words JOIN CALL, in your contact list,

(iii) Next point the cursor to the green cylindrical tab with the words JOIN CALL,

(iv) Your screen will enter the LSINJ - Webinar Group I, and there should be a collage of pictures of other Board Members of the chat group who have already joined the call.

Troubleshooting assistance with the Skype call

For assistance with the Skype call please refer to these links extracted from their website. The Skype group calling, including conference calling and group chats, has been updated to simultaneously include up to 100 people.

(1) https://www.skype.com/en/get-skype

(2) https://www.skype.com/en/features/group-calls/

Skype support in place should the call fail (Links 3 and 4):

(3) https://go.skype.com/help.faq.groupcalls

(4) https://support.skype.com/en/faq/fa10613/how-do-i-make-a-call-in-skype

The time conversion charts below adjusted on November 5th 2023 are adjusted for US Daylight Savings Time. 

West -> East:

5.30 am (Honolulu, Hawaii, USA) -> 7.30 am (Seattle, WA/Portland, Oregon, PST US) -> 9.30 am (San Antonio, TX)  -> 10.30 am (New York, NY; Greenville, NC; Miami, FL; Montréal, Quebec, Canada) -> 12.30 pm (Santiago, Chile) -> 3.30 pm (London, UK, Europe) -> 4.30 pm (The Ramstad, Amsterdam, The Netherlands, Europe) -> 3.30 pm (Cassablanca, Morocco, Africa) -> 4.30 pm (Lagos, Lapai, Nigeria, Africa time) -> 6.30 pm (Istanbul, Turkey) -> 7.00 pm (Isfahan, Tehran Iran) -> 10.00 pm (Mumbai, Uttarakhand, Lucknow , India) -> 10.00 pm (Colombo, Sri Lanka) -> 10.30 pm (WIB time, Tangerang, Banten, Jakarta, Indonesia).

These are all the links from the TimeBie time converter application for re-checking the times. They cover the locations from the FWD of the LSINJ (Seattle/Portland (PST US) to the FED of the LSINJ (Tangerang, Banten, Jakarta, Indonesia (WIB) all adjusted for US DST:

www.timebie.com/

    https://timebie.com/timezone/honolulusanfrancisco.php

    http://www.timebie.com/timezone/sanantoniosanfrancisco.php

    http://www.timebie.com/timezone/sanfrancisconewyork.php

    http://www.timebie.com/timezone/londonsanfrancisco.php

    https://www.timebie.com/tz/timediff.php?q1=San%20Francisco%20Time&q2=Santiago%20Time

      http://www.timebie.com/timezone/pacificdaylightmorocco.php

      http://www.timebie.com/timezone/nigeriaseattle.php

    http://www.timebie.com/timezone/istanbulsanfrancisco.php 

    http://www.timebie.com/tz/timediff.php?q1=Tehran%20Time&q2=San%20Francisco%20Time

     http://www.timebie.com/timezone/mumbainewyork.php

     http://www.timebie.com/timezone/indianewyork.php

     http://www.timebie.com/timezone/srilankaseattle.php

     http://www.timebie.com/timezone/jakartaseattle.php

The webinar series features a Speaker and a topic to which conversation is generally limited. While administrative meetings are separately discussed. However, webinars present an opportunity for BM to meet in person, through introductions, albeit in cyberspace.

We look forward to seeing all BM at Prof. Musa's webinar - and others that will follow.

Best regards,

Ferez

Ferez S. Nallaseth, MS, PhD

Founding President, CEO, CSO, CFO & Principal Donor

Life Sciences Institute of New Jersey

2468 US Highway 206, P.O. Box 1367

Belle Mead, New Jersey 08502- 6430, USA

Email Addresses: FerezNallaseth@lifesciencesinstitutenj.com  

Tel: 646 283 5163 (M)

      908 431 5069 (LSINJ)

Skype Address: ferez.nallaseth

Personal and Professional Websites:

LSINJ-ConsolidatedWebsiteSignat.9.30.2018.pdf

Report & Recording: 

Report: 33rd LSINJ Webinar, 1.27.2024: SVP/Prof./Director, Dickson A. Musa: 'Leveraging Nigeria's Rich Biodiversity for Improved Health and Sustainable Development'

Recording: https://drive.google.com/file/d/1fzucbdCrg47vZs9WKGJzlRKOiPxozX4p/view?usp=drive_link

By Fnd. Pres., CEO, CSO & CFO, Ferez D. Nallaseth, MS, PhD

SVP/Prof./Dir., Dickson Achimugu Musa, PhD presented the rescheduled 33rd LSINJ Webinar entitled ‘Leveraging Nigeria's Rich Biodiversity for Improved Health and Sustainable Development’ on Saturday, January 27th, 2024. It was well attended and drew active participation from BM located in multiple towns, universities, research centers and cities located in at least 4 nations and on 3 continents. Prof. Musa had shared the link to the ongoing webinar with the Trans Saharan Disease Research Center (TDRC), IBB University and an audience presumably located across Africa as well as other continents. This participation occurred despite the wide disparities of time zones. The active participation by BM during the follow-up question period displayed the keen interest generated by a clear delivery of a high scientific standard.

Prof. Musa opened the webinar with a coverage of the magnitude of Nigerian Biodiversity and the state of the fields of Pharmaceutical and Biotechnological research and industry. Representing both the resistance to accepting traditional herbal medicine as well as propensity for time tested pharmaceutical products even when their reliability and effectiveness had faded into being ineffective. Furthermore, compounding these factors, the technical and chemical extraction processes of biochemically purifying compounds from herbal sources were of low efficiency. However, more recently Prof. Musa drew attention to traditional allopathic drugs such as antibiotics having lost their effectiveness with an inability to contain several microbial infections. Part of the recognized reason for this loss is the gratuitous use in healthcare as well as agriculture selecting for antibiotic resistance. Additionally, technical limitations to extraction, biochemical purification and standardization of herbal extracts are now ameliorated if not minimized. Therefore, permitting their increased acceptance and deployment in the pharmaceutical community with good results. The power of purified, tested and validated herbal biochemical compounds in their effectiveness, against specific pathological, bacterial and viral test subjects, such as Salmonella and MS 2 phage was also highlighted in the results presented by Prof. Musa. The effectiveness of these compounds was measured and determined from biochemical, cellular, and microbial indices.

In the quest to improve effectiveness and spectra of targets of some purified herbal compounds Prof. Musa and his colleagues applied innovative approaches in protein chemistry namely protein-ligand interactions. By fixing protein mobility and permitting the ligand to rotate/pivot the group identified preferred stabilities and binding constants which were then deployed. Finally, Prof. Musa highlighted the growing recognition of the global loss of Biodiversity by extensive and unregulated logging of forests. On a wider scale of a longer lasting impact ameliorating the threatened loss of Biodiversity and its resources Prof. Musa and his colleagues proposed setting up and mandating a protected Biodiversity Park in Nigeria.

Prof. Musa finished with acknowledging all those in his scientific, professional, academic, and personal life who made possible his many contributions.

The audience participation was active and elicited further interest and clarification. It included Prof. Musa fielding a series of questions with good responses. They questions by SVP/Treasurer Ralph Sherman, BS.  VP David Adebayo, DBE, SVP Egbenoma A. Aigboeghian, MS, and myself.

Webinar Title: Leveraging Nigeria's Rich Biodiversity for Improved Health and Sustainable Development 

Speaker Titles: 'Director: Trans-Saharan Disease Research Centre, IBB University, Lapai, Nigeria

Senior Vice President (Genetic Diversity & Microbial Ecosystems): Life Sciences Institute of New Jersey, Belle Mead NJ, USA'  

External Affiliations and Profile on the LSINJ website:  Director of Trans - Saharan Disease Research Center, IBB University, Lapai, Nigeria; Deputy Dean, Faculty of Natural Sciences , Ibrahim Badamasi Babangida (IBB) University, Lapai, Nigeria; Professor and Head, Department of Biochemistry, Faculty of Natural Sciences IBB University, 911101, Lapai, Niger State, Nigeria; Public Relations Officer, Nigerian Society of Biochemistry and Molecular Biology; Chairman, North Central Zone, Biotechnology Society of Nigeria

Link to Full Profile on the LSINJ website: https://www.lifesciencesinstitutenj.com/board-members#h.p_z84hVpgP5g6k